丁二酸洛沙平与盐酸氯丙嗪治疗精神分裂症的比较  

STUDY ON THE EFFICACY OF LOXAPINE IN TREATMENT OF SCHIZO PHRENIA IN COMPARISON WITH CHLORPROMAZINE

作　　者：黄淑贞[1,2,3] 秦英绂[1,2,3] 王渌生 王振环[1,2,3] 马崔 郑洪波 

机构地区：[1]北京安定医院 [2]天津市安定医院 [3]广州市精神病院

出　　处：《中国新药杂志》1997年第3期161-164,共4页Chinese Journal of New Drugs

摘　　要：用随机双盲双模拟法比较了国产丁二酸洛沙平与盐酸氯丙嗪治疗２０５例精神分裂症的研究结果。洛沙平组１０４例，氯丙嗪组１０１例，疗程８周。结果显示：两组疗效相似，有效率均为８９．１％，洛沙平组显效率６１．４％，氯丙嗪显效率４９．５％。洛沙平作用起效快且持久，对青春型的ＢＰＲＳ总分减分率与氯丙嗪组有显著的差异（Ｐ＜０．０５）。两组副作用基本相似。洛沙平的主要副反应有静坐不能、便秘、震颤、出汗，个别病例有心电图ＳＴＴ段的改变及癫痫大发作。The randomized,double blind study involved 205 patients with schizophrenia.104 patients were randomized to receive loxapine succinate for 8 weeks,while 101 patients were randomized to receive chlorpromazine hydrochloride for 8 weeks.Results showed that a same response rate of 89.1% were obtained in both groups,while an obviously effective rates of 61.4% and 49.5% were obtained in loxapine group and chlorpromazine group respectively.Loxapine which has a rapid onset of effect and long duration of action,is superior to chlorpromazine on basis of BPRS(P<0.05) in treatment of hebephrenia.Akathisia,constipation,tremor and sweating are the main ADRs of loxapine and epileptic seizures and abmormal ECG are seldom occure to it.

关 键 词：精神分裂症 丁二酸洛沙平 盐酸氯丙嗪 药物疗法 

分 类 号：R749.305[医药卫生—神经病学与精神病学]