幽门螺杆菌感染与胃癌浸润转移及相关因子表达的关系探讨  

The Correlations Among Helicobacter Pylori Infection,Expressions of Some Factors and Invasiveness and Metastasis Gastric Carcinoma

作　　者：施宏[1] 陈素玉[1] 陈刚 周东[1] 林贤东[1] 严俊[1] 沈武成[1] 

机构地区：[1]福建省肿瘤医院,福建医科大学教学医院,福州350014

出　　处：《临床消化病杂志》2007年第3期170-171,175,共3页Chinese Journal of Clinical Gastroenterology

基　　金：福建省肿瘤医院科研资助项目(K-2004016)

摘　　要：目的研究幽门螺杆菌(Hp)感染和fas、fasL、c-myc、VEGF表达与胃癌浸润转移的关系,探讨其可能作用机制。方法采用快速尿素酶试验及病理切片Giemsa染色检测Hp感染,免疫组化检测fas、fasL、c-myc、VEGF表达。结果Hp阳性组中VEGF、c-myc表达均高于Hp阴性组。VEGF表达率越高,分期越晚。结论Hp作为致癌物质,可能通过VEGF、c-myc参与胃癌发生发展,VEGF对胃癌浸润转移具有一定作用。Objective To investigate helicobacter pylori （Hp） infection and expressions of fas, fasL, c-myc, VEGF in gastric carcinoma, and their associations with invasion and metastasis of gastric cancer. Methods Hp infection was assessed by using the rapid urease rest and section- staining. Immunohistochemical staining was used to detect the expressions of fas, fasL, c-myc, VEGF. Results The expression rates of c-myc, VEGF in Hp positive group were higher than those in Hp negative group. The higher VEGF expressed, the later the stage lay. Conclusion Hp might act as a tumor promoter during the genesis of gastric carcinoma by influencing the expressions of c-myc, VEGF. There are some relationships between the expression of VEGF and the invasion and metastasis of gastric cancer.

关 键 词：胃癌 幽门螺杆菌 浸润转移 相关因子 

分 类 号：R735.2[医药卫生—肿瘤]