低氧诱导因子-1α在溃疡性结肠炎中的表达  

Expression of hypoxia-inducible factor-1alpha (HIF-1α) in ulcerative colitis (UC)

作　　者：许春梅 刘波 

机构地区：[1]湖北省襄樊市第一人民医院消化内科,湖北襄樊441000

出　　处：《中国现代医学杂志》2007年第11期1389-1392,共4页China Journal of Modern Medicine

基　　金：武汉市科技局资助项目(No:301121017)

摘　　要：目的探讨低氧诱导因子-1α(HIF-1α)在溃疡性结肠炎(UC)组织中的表达及与疾病活动性的关系。方法采用免疫组织化学方法检测47例UC患者(活动期35例、缓解期12例)和20例正常对照组中HIF-1α的表达。结果溃疡性结肠炎患者活动期HIF-1α表达显著高于正常人,差异有显著性(152.27±16.26)vs(193.28±16.65)(P<0.01),缓解期HIF-1α表达与正常人差异无显著性(185.93±11.80)vs(193.28±16.65)(P>0.05),溃疡性结肠炎中HIF-1α的表达与Walmsley评分标准有相关性,且呈正相关。结论HIF-1α作为一种转录因子可能参与了UC的发病过程并与疾病的活动性有关。[Objective] To investigate the expression of HIF-1α in the tissues of patients with UC and its relationship with activity of UC. [Methods] Immunohistochemistry assay was performed to detect the expression of HIF-1α in the samples from 35 cases with UC in active stage, 12 cases at stable stage, and 20 cases in normal control. [Result] The expression of HIF-1α was higher in patients with UC at active stage than that in the controls （152.27±16.26） vs （193.28±16.65）, P 〈0.01, while the expression of HIF-1α in UC at stable stage was not significantly different from that in the controls （185.93±11.80） vs （193.28±16.65）, P 〉0.05. The level of HIF-lαin the tissues in active UC was positively correlated with the Walmsley renal scoring （r =0.53I, P =0.001）. [Conclusion] HIF-1α as a transcriptional factors may be involved in the pathogenesis and activity of UC.

关 键 词：溃疡性结肠炎 低氧诱导因子-1Α 免疫组化 

分 类 号：R574.62[医药卫生—消化系统]