HBV感染肝癌患者血清HBV DNA水平与手术近期疗效的关系  

THE RELATIONSHIP BETWEEN THE LEVEL OF HBV DNA IN SERUM AND THE RECENTLYOPERATIVE EFFECT OF PRIMARY HEPATOCARCINOMA WITH HBV INFECTION

作　　者：蔡欣然[1] 黄长玉[1] 周浩辉[1] 周良艺[1] 

机构地区：[1]福建医科大学附属协和医院,福州350001

出　　处：《肝胆外科杂志》2007年第3期175-177,共3页Journal of Hepatobiliary Surgery

基　　金：福建省自然科学基金计划资助项目(编号C0310020)

摘　　要：目的探讨血清HBVDNA水平与HBV感染原发性肝癌手术治疗近期疗效的关系。方法100例HBsAg阳性手术切除的原发性肝癌病例,检测术前、术后1周血清HBVDNA,与各项临床指标,术后血ALT、TB峰值及肝功能恢复时间行统计学分析。结果本组病例术前HBVDNA阳性率达79%,肝切除前后血清HBVDNA水平变化无显著性差异(配对t检验P=0.204);术前血清HBVDNA水平与肝癌切除后血清ALT峰值及肝功能恢复时间呈显著性正相关(P<0.05)。结论乙肝病毒感染的肝癌患者多数处于HBV活跃期,肝癌切除术对血清HBVDNA水平无明显影响,但术前血清HBVDNA高水平将导致肝切除术后肝功损害加重及恢复时间延长。Objective Investigate The relationship between the level of HBV DNA in serum and the recently operative effect of PHC. Methods The preoperative and one week post preoperative serum HBV DNA level were measured by PCR in 100 PHC patients with HBsAg positive, the clinical features and the change of postoperative liver function were analized by SPSS software. Results 1. The positive rate of serum HBV DNA in all cases of PHC was 79%. 2. The serum HBVDNA level in preoperation was not significantly different with that in postoperation. （ Paried-samples T-test P =0. 204 ） 3. The preoperative serum HBV DNA level was signifi- candy positive correlated with the peak value of serum HBV DNA level and the recovery period of liver function after hepatectomy. Conclusions The most of PHC patients with HBV infection were in the active phase of HBV infection ; the serum HBV DNA level was not influenced by the hepatectomy; but the high level of serum HBV DNA would result in the aggravation of hepatic dysfunction and the extend of liver function recovery.

关 键 词：HBVDNA 肝癌 肝切除术 

分 类 号：R735.7[医药卫生—肿瘤]