血液稀释疗法对不同月龄大鼠脑卒中后心肌酶活性的影响  

The effects of hemodilution on activity of myocardial enzyme in adult and old rats with cerebral stroke for 24 hours

作　　者：马宁[1] 张北奇[1] 周锡英[1] 张硕立[1] 于占久[1] 朱方[2] 

机构地区：[1]河北省医学科学院 [2]河北医科大学基础医学院

出　　处：《中国老年学杂志》1997年第2期95-97,共3页Chinese Journal of Gerontology

基　　金：河北省科委课题

摘　　要：应用４～５月龄成年鼠和２４月龄以上老年Ｗｉｓｔａｒ大鼠，分别在外科手术显微镜下采用电灼法造成大鼠一侧大脑中动脉闭塞２４ｈ后进行血液稀释治疗２ｈ，检测心肌酶活性。结果表明：脑卒中后心肌损伤程度以老年大鼠为重，经血液稀释治疗后，心肌组织Ｎａ＋－Ｋ＋－ＡＴＰａｓｅ，Ｃａ２＋－ＡＴＰａｓｅ，超氧化物歧化酶（ＳＯＤ），丙二醛（ＭＤＡ）和Ｎ－乙酰－β－Ｄ－氨基葡萄糖苷酶ＮＡＧａｓｅ两个年龄组均有一定程度的变化，以成年组治疗效果优于老年组大鼠，说明血液稀释对闭塞单侧大脑中动脉所致成年、老年大鼠心肌损伤有一定的治疗作用。The origin left middle cerebral artery(LMCLA) in adult(about 4～5 monthes) & old(over 24 monthes) rats was blocked by galvanic cautery under stereoscopic microscope, 24 hours later, the rat models of cerebral stroke, were treated by hemodilution with normal salt lasted 2 hours. The levels of SOD, MDA, NAGase, Na + K + ATPase and Ca 2+ ATPase in myocardial tissue of the adult & old rats were measured. The results showed that SOD, Ca 2+ ATPase were increased in myocardium treated by hemodilution, while the NAGase and MDA decreased. It is suggested that hemodilution can improve enzyme activity in damaged myocardium after the cerebral stroke and the protective effect in adult rat is better than the old rats.

关 键 词：血液稀释 脑梗塞 心肌细胞 氧自由基 老年人 

分 类 号：R743.33[医药卫生—神经病学与精神病学]