进展性缺血性卒中血浆血栓素B_2及6-酮-前列腺素F1a的研究  

Study of throm boxane B_2 and 6-keto-PGF1a in patients with ischemic stroke in progression

作　　者：丁俊丽[1] 银广悦[2] 檀培芳[3] 李立祥[4] 

机构地区：[1]中国石油天然气集团公司中心医院神经内科 [2]中国石油天然气集团公司中心医院检验科 [3]中国石油天然气集团公司中心医院神经内科教研室 [4]中国石油天然气集团公司中心医院科教处

出　　处：《中国现代医药杂志》2007年第6期10-12,共3页Modern Medicine Journal of China

摘　　要：目的分析血浆血栓素B_2(TXB_2)及6-酮-前列腺素F1a(6-keto-PGF1a)与进展性缺血性脑卒中早期进展的相关性及临床意义。方法检测患者及健康对照组外周血血浆TXB_2及6-keto-PGF1a水平,分析其在缺血性卒中组、进展性缺血性卒中组与健康对照组水平的差异。结果缺血性脑卒中组血浆TXB_2、血浆血栓素B_2/血浆6-酮-前列腺素F1a(T/P)比值高于健康对照组,6-keto-PGF1a低于健康对照组,有统计学意义(P<0.05);进展性缺血性卒中组血浆TXB_2、T/P高于非进展性缺血性卒中组,6-keto-PGF1a低于非进展性缺血性卒中组,有统计学意义(P<0.05)。结论TXB_2、6-keto-PGF1a不仅参与缺血性卒中后急性期反应,而且与进展性缺血性卒中密切相关,可以作为进展性缺血性卒中的预警因子。Objective Analyse the re1ation and the clinical significance of p1asma throm boxane B2 and 6-keto- PGF1a to ischemic stroke in progression in its early progressing time.Method To detect the levels and to analyse the difference of p1asma throm boxane B2 and 6-keto-PGF1a in the ischemic stroke group,ischemic stroke in progression group and health control group. Results The level of p1asma throm boxane B2 and the rate of p1asma throm boxane B2/6-keto-PGF1a in ischemic stroke group was higher than that of health control group, The level of p1asma 6-keto-PGF1a in ischemic stroke group was lower than that of health control group （P〈0.05）. The level of p1asma throm boxane B2 and the rate of p1asma throm boxane B2/6-keto-PGF1a in ischemic stroke in progression group was higher than that of non- ischemic stroke in progression group. The level of p1asma 6-keto-PGF1a in ischemic stroke in progression group was lower than that of non-ischemic stroke in progression group（P〈0.05）. Conclusion The levels of p1asma throm boxane B2 and 6-keto-PGF1a following cerebral infarction are associated with ischemic stroke in progression, can be used as one of the important indexes of forecasting stroke in progression.

关 键 词：进展性缺血性卒中 血栓素B2 6-酮-前列腺素F1A 

分 类 号：R743.3[医药卫生—神经病学与精神病学]