人肺组织 DNA 加合物含量的某些影响因素分析  

The influence of some factors on DNA adduct levels in human lung tissue

作　　者：吕京[1,2] 杨柯[1,2] 崔涛[1,2] 谢汇江 张海青 孟庆海[1,2] 赵志文[1,2] 贺锡雯[1,2] 

机构地区：[1]中国预防医学科学院劳动卫生与职业病研究所 [2]北京市结核病胸部肿瘤研究所

出　　处：《中华劳动卫生职业病杂志》1997年第3期138-141,共4页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：国家自然科学基金

摘　　要：为探讨人肺组织ＤＮＡ加合物的形成与某些影响因素之间的关系，分析了３７例肺癌患者（男１９例、女１８例）及３７例非肺癌肺部疾病患者（男１９例、女１８例）肺组织ＤＮＡ加合物的含量与年龄、性别、吸烟等影响因素之间的关系。结果表明：引起肺组织ＤＮＡ加合物含量增高的主要因素是吸烟；年龄、性别与肺组织ＤＮＡ加合物含量无相关性。To study the influence factors on DNA adduct levels in human lung tissue. DNA adduct levels in lung tissues obtained both from lung cancer patients (male 19 and female 18) and non lung cancer patients(male 19 and female 18) were analyzed by 32 P postlabelling assay.The results showed that DNA adduct levels in lung tissues were increased significantly by smoking;neither correlation with age nor difference between sexes was found.

关 键 词：癌 DNA加合物 吸烟 性别 年龄 肺肿瘤 肺疾病 

分 类 号：R734.202[医药卫生—肿瘤] R563.02[医药卫生—临床医学]