巨大型侵袭性垂体腺瘤癌基因相关蛋白的研究  

The study on the expression of oncogene associating protein in macro-invasive pituitary adenomas.

作　　者：庞 陈衔城[1] 李士其[1] 

机构地区：[1]上海医科大学附属华山医院神经外科,200040

出　　处：《中国神经精神疾病杂志》1997年第3期134-136,共3页Chinese Journal of Nervous and Mental Diseases

摘　　要：目的　研究癌基因产物c -erbB2 、EGFR、P2 1 及增殖细胞核抗原 (PCNA)在巨大型侵袭性垂体腺瘤中的表达。　　方法　采用免疫组织化学方法 (ABC法 )测定上述蛋白在 67例该类肿瘤和 2 2例非侵袭性肿瘤中的表达。　　结果　巨侵型腺瘤中PCNA ,c erbB2 的阳性表达高于非侵袭性腺瘤 ;巨侵型腺瘤中细胞间变组的PCNA、c erbB2 、EGFR及P2 1 的阳性表达高于非间变组。　　结论　垂体瘤的侵袭性生长方式及其细胞间变与基因水平的调控障碍有关 。Objective To study the expression of oncogene product: c erbB 2, EGFR, P 21 and cell proliferation related protein PCNA in the giant invasive pituitary adenomas Methods The expression of the protein mentioned above was observed by immunohistochemical approach (ABC method) in 67 tumors Results The invasive tumors had a higher expression of PCAN and c erbB 2 than non invasive tumors; among the invasive tumors, those tumors with metaplasia had a higher expression of PCNA, c erbB2, EGFR and P21 than those without metaplasia Conclusions The invasive growth and the cell metaplasia of the pituitary adenomas were related to the disorder of the function of the oncogenes, and the progresis could be judged by the expression level of special proteins such as PCAN

关 键 词：垂体肿瘤 侵袭性 癌基因 腺瘤 巨大型 基因表达 

分 类 号：R736.402[医药卫生—肿瘤]