Intraocular complications of IFN-α and ribavirin therapy in patients with chronic viral hepatitis C  

作　　者：Damien Sène Valérie Touitou Bahram Bodaghi David Saadoun Gabriel Perlemuter Nathalie Cassoux Jean-Charles Piette Phuc Le Hoang Patrice Cacoub 

机构地区：[1]Department of Internal Medicine, Hpital Pitié-Salpêtrière, Paris, France [2]Department of Ophtalmology, Hpital Pitié-Salpêtrière, Paris, France [3]Department of Hepatogastroenterology, Hpital Antoine Béclère, Clamart. France

出　　处：《World Journal of Gastroenterology》2007年第22期3137-3140,共4页世界胃肠病学杂志（英文版）

摘　　要：We report a panel of severe inflammatory and vascular intraocular disorders occurring during interferon-alpha （IFN-α） treatment in eight hepatitis C virus （HCV）- infected patients. These events include three cases of Vogt-Koyanagi-Harada like （VKH） disease （an association of panuveitis, retinal detachment, ear and meningeal detachment and skin and hair changes）, two cases of central retinal vein occlusion, one case of central retinal artery occlusion, one case of severe hypertensive retinopathy and one case of bilateral ischemic optic neuropathy with severe visual impairment. Rare as they are, such severe ophthalmological complications require a close follow-up of HCV-infected patients under IFN-α breabnent with ophthalmological monitoring if any ocular manifestation occurs.We report a panel of severe inflammatory and vascular intraocular disorders occurring during interferon-alpha (IFN-α) treatment in eight hepatitis C virus (HCV)-infected patients. These events include three cases of Vogt-Koyanagi-Harada like (VKH) disease (an association of panuveitis, retinal detachment, ear and meningeal detachment and skin and hair changes), two cases of central retinal vein occlusion, one case of central retinal artery occlusion, one case of severe hypertensive retinopathy and one case of bilateral ischemic optic neuropathy with severe visual impairment. Rare as they are, such severe ophthalmological complications require a close follow-up of HCV-infected patients under IFN-α treatment with ophthalmological monitoring if any ocular manifestation occurs.

关 键 词：Hepatitis C virus INTERFERON-ALPHA Intra-ocular complications Central retinal vein occlusion Central retinal artery occlusion Acute anterior ischemicoptic neuritis Vogt-Koyanagi-Harada like disease 

分 类 号：R512.6[医药卫生—内科学]