p^(53)与C-erbB_2、C-ras、C-myc在卵巢粒层细胞瘤中的过度表达及其临床意义  

Study on the overexpressions of p 53 and C erbB 2,C ras,C myc in granulosa cell tumor(GCT) of the ovary and their correlations with the development of GCT.

作　　者：崔保霞[1] 张文尧[1] 江森[1] 张振国[1] 杨兴升[1] 

机构地区：[1]山东医科大学附属医院

出　　处：《现代妇产科进展》1997年第2期114-118,共5页Progress in Obstetrics and Gynecology

摘　　要：目的：了解ｐ５３及Ｃ－ｅｒｂＢ２、Ｃ－ｒａｓ、Ｃ－ｍｙｃ在卵巢粒层细胞瘤中的表达及与此瘤发生、发展的关系。方法：采用单克隆抗体免疫组化技术，对２５份卵巢粒层细胞瘤组织进行ｐ５３、Ｃ－ｅｒｂＢ２、Ｃ－ｒａｓ及Ｃ－ｍｙｃ表达的检测，分析基因表达与临床－病理指标及患者预后的关系。结果：２５例卵巢粒层细胞瘤中ｐ５３、Ｃ－ｅｒｂＢ２、Ｃ－ｒａｓ、Ｃ－ｍｙｃ的过度表达率分别为５６％、５６％、４８％、４８％。Ⅲ～Ⅳ期ｐ５３的过度表达高于Ⅰ～Ⅱ期；有残余瘤者较无残余瘤者显著增高。Ⅲ～Ⅳ期的Ｃ－ｅｒｂＢ２过度表达率显著高于Ⅰ～Ⅱ期者。高分化组的Ｃ－ｒａｓ基因过度表达率显著高于低分化组。未发现Ｃ－ｍｙｃ的表达与临床－病理各指标有关。两种及两种以上基因同时表达者显著高于单基因表达者。ｐ５３与Ｃ－ｅｒｂＢ２及Ｃ－ｍｙｃ过度表达间呈正相关。临床分期及Ｃ－ｅｒｂＢ２的过度表达是独立影响患者预后的因素。结论：ｐ５３及Ｃ－ｅｒｂＢ２、Ｃ－ｒａｓ、Ｃ－ｍｙｃ的表达对卵巢粒层细胞瘤的发生、发展及患者预后有一定的影响。Objectives:To determine the overexpressions of p 53 and C erbB 2,C ras,C myc in GCT of the ovary,and to analyse their correlations with the development of GCT. Methods:Overexpressions of p 53 and C erbB 2,C ras,C myc were determined by immunohistochemistry in paraffin embedded tumor tissues from 25 patients with GCT. Results:The incidences of overexpression of p 53 and C erbB 2,C ras,C myc were 56%(14/25),56%(14/25),48%(12/25),48%(12,25),respectively.p 53 overexpression rate in stages Ⅲ/Ⅳ was higher than that in stages Ⅰ/Ⅱ;patients with residual tumor after initial surgery was higher than those without residual tumor too.C erbB 2 immunoreactivity was higher in tumors with stages Ⅲ/Ⅳ than that in tumors with stages Ⅰ/Ⅱ.C ras overexpression was associated with tumor differentiation.The overexpression rates of more than two oncoproteins were higher than those with expression of one oncoprotein.p 53 overexpression correlated with overexpression of C erbB 2 and C myc.According to the FIGO staging and the C erbB 2 expression were independent variables for predicting patients' prognosis. Conclusions:Overexpressions of p 53 and C erbB 2,C ras,C myc have some effects on carcinogenesis,tumor progression and prognosis of patients with GCT.

关 键 词：卵巢肿瘤 粒层细胞瘤 P53基因 癌基因 

分 类 号：R737.310.2[医药卫生—肿瘤]