恶性妊娠性滋养细胞肿瘤患者保存生育力的研究  

The treating methods of malignant gestational trophoblastic diseases with preservation of patients' fertility.

作　　者：王骅[1] 李孟达[1] 林妙卿 

机构地区：[1]中山医科大学肿瘤医院

出　　处：《现代妇产科进展》1997年第2期127-129,共3页Progress in Obstetrics and Gynecology

摘　　要：目的：探讨恶性妊娠性滋养细胞肿瘤（ＧＴＴ）患者保存生育力的治疗方法。方法：长期随访１９６４年４月至１９９３年１２月成功保存子宫的１３３例恶性ＧＴＴ，其中侵蚀性葡萄胎１０１例，绒毛膜癌３２例。结果：１３３例中仅１例１２年后复发，子宫无病变。患者治愈后的怀孕率达９１．６％。结论：通过单纯化疗，恶性ＧＴＴ能够治愈并保存生育能力。在全身化疗的基础上，应根据病情和转移病灶的部位采用相应的局部化疗，以提高疗效，减少疗程与用药量和减少抗癌药对患者生育力、妊娠后胚胎发育过程及后代的可能影响。Objective To investigate the treating methods of malignant gestational trophoblastic diseases. Methods 133 cases(consisted of 101 cases of invasive mole and 32 cases of choriocarcinoma)from April 1964 to December 1993 treated in Department of Gynecology,Tumor Hospital,Sun Yatsen University of Medical Sciences,were successfully recovered with preservation of patients' fertility.The method of treatment was systemic chemotherapy combined with local(regional) chemotherapy such as intraarterial,intrathecal and local infussion around the lesion. Results:There was only one case recurred with no lesions in the uterus pathologically after 12 years of primary treatment.The rate of pregnancy in 107 cases,who wanted to have children after complete recovery,was 91.6%.Totally 182 pregnancies and 121 babies were obtained. Conclusions It is possible to recover completely from malignant gestational trophoblastic diseases with preservation of fertility.In order to do so,the treatment should base on chemotherapy.In addition to systemic chemotherapy,and regional chemotherapy are a preferable methods.Regional chemotherapy can lead to a better result and reduce the side effects to the patients' fertility as well as the possible damage to the pregnancy and children later on.

关 键 词：滋养细胞肿瘤 妊娠性 癌 生育力 

分 类 号：R737.330.1[医药卫生—肿瘤]