脑梗死患者调脂干预对颈动脉硬化及血清C反应蛋白的影响  

Effect of simvastatin on arteriosclerosis plaque of carotid artery and high sensitive C-reactive protein in patients with cerebral infarction

作　　者：洪柳[1] 莫亚杰[1] 

机构地区：[1]广东省农垦中心医院,湛江524002

出　　处：《中国实用神经疾病杂志》2007年第4期8-10,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨辛伐他汀对脑梗死患者血清高敏C反应蛋白(hs-CRP)和颈动脉粥样硬化的影响及机制。方法120例脑梗死伴颈动脉粥样硬化患者,随机分为2组:治疗组60例,在常规治疗基础上加服辛伐他汀20mg,治疗6个月及12个月前后血清hs-CRP的浓度及经彩色多普勒技术测定颈动脉内膜厚度,血流参数及颈动脉斑块的变化,并与常规治疗60例作对照组。结果60例脑梗死伴颈动脉粥样硬化者经辛伐他汀治疗6个月后血清hs-CRP的测定值显著低于治疗前水平(P<0.05或P<0.01),并降低双侧颈动脉内膜厚度,斑块面积缩小,改善颈动脉血流参数,12个月后上述各项参数改变更为明显,与常规治疗对照组及治疗前比较,差异有显著性(P<0.01)。结论辛伐他汀通过抗炎等机制对防治脑梗死早期动脉粥样硬化以及稳定斑块起着重要的作用。Objective To observe the influence of simvastatin onplaque and serum high sensitive C- reactive protein （hs- CRP） levels and arteriosclerosis plaque of carotid artery in patients with cerebral infarction. Methods Sixty subjects with arteriosclerosis plaque of carotid artery were given simvastatin 20mg qd for 12 months. The serum levels of hs-CRP were detected before and 6 months aftertr eatment. The intima-media thickness （IMT） and arteriosclerosis plaque of carotid artery were measured before and 6 and 12 months after treatment in all patients with Doppler ultrasonograph. Results After 6 and 12 months adminstration of simvatatin, the levels of hs-CRP were all reduced （P〈0.01）. The initial diameter of carotid artery was significantly enlarged （P〈0. 01）. The size of plaque and IMT reduced significantly in 12 months after simvastatin therapy （P〈0. 01）. All the parameters of blood flow in carotid artery were improved significantly （P〈0.01）. Conclusion Simvastatin decreased inflammatory reaction in patient with cerebral infarction,which may improve stabilization of the plaque in carotid artery.

关 键 词：脑梗死 脂类和降血脂药 颈动脉粥样硬化 C反应蛋白 

分 类 号：R743.33[医药卫生—神经病学与精神病学]