Lipo PGE1治疗蛛网膜下腔出血后脑微循环障碍的改善  

Effects of lipid microspheres prostaglandin E1 on microcirculation deficit of subarachnoid hemorrhage

作　　者：文立[1] 李善泉[1] 戴炯[1] 

机构地区：[1]上海交通大学医学院仁济医院神经外科,上海200001

出　　处：《上海交通大学学报（医学版）》2007年第3期249-252,共4页Journal of Shanghai Jiao tong University:Medical Science

摘　　要：目的观察前列腺素E1脂微球载体制剂(Lipo PGE1)治疗蛛网膜下腔出血(SAH)后脑微循环障碍的改善。方法自发性SAH患者93例,随机分为Lipo PGE治疗组(n=65)和对照组(n=28)。Lipo PGE1治疗组静脉滴注Lipo PGE1,同时行其他传统治疗方法;对照组不使用Lipo PGE1,其余治疗措施同治疗组。观察两组治疗前后影像学、血浆和脑脊液生化指标的改变及脑血管痉挛的发生情况。结果Lipo PGE1治疗组脑血管痉挛的发生率较低,两组存在统计学差异(P<0.05);在治疗后第3、7天,Lipo PGE1治疗组vWF和GMP-140水平明显低于对照组(P<0.05,P<0.01);两组再出血发生率无统计学差异(P>0.05)。结论Lipo PGE1能降低SAH后脑血管痉挛发生率,改善脑微循环障碍。Objective To investigate the effects of lipid microspheres prostaglandin E1 （Lipo PGE1） on subarachnoid hemorrhage （SAH）. Methods Ninty-three patients with SAH were randomly divided into control group （ treated with nomal drugs） and Lipo PGE1 treatment group （treated with nomal drugs and Lipo PGE1 ）. Changes in neuroimaging, biochemical indexes and incidence of cerebral vasospasm were measured. Results A lower incidence rate of cerebral vasospasm was observed in Lipo PGE1 treatment group （P 〈 0.05） , while no significant difference was identified in the incidence rate of rehemorrhage between the two groups （.P 〉 0.05 ）. The levels of vWF and GMP-140 were significant lower in the Lipo PGE1 treatment group than those in the control group after treatment for 3 and 7 d （ P 〈 0.05,P 〈 0.01 ）. Conclusion Lipo PGE1 can decrease the incidence rate of cerebral vasospasm and alleviate the neurological deficit after SAH.

关 键 词：前列腺素E1 蛛网膜下腔出血 脑血管痉挛 

分 类 号：R743.34[医药卫生—神经病学与精神病学]