盐酸多奈哌齐对正常成年大鼠学习和记忆功能的影响  

Effect of donepezil hydrochloride on learning and memory function in normal adult rats

作　　者：谢湘林[1] 刘宏雁[1] 李颖[2] 刘凯[1] 李晔[1] 吴轶川[1] 臧晓峰[1] 叶秋芳[1] 马春颖[1] 

机构地区：[1]吉林大学药学院药理学教研室,吉林长春130021 [2]吉林大学基础医学院病理生物学教育部重点实验室,吉林长春130021

出　　处：《吉林大学学报（医学版）》2007年第3期467-469,共3页Journal of Jilin University：Medicine Edition

基　　金：吉林省科技厅资助课题(20030551-1)

摘　　要：目的：探讨盐酸多奈哌齐（DPH）对正常成年大鼠学习、记忆功能的影响。方法：采用区组随机分组方法按体重随机将Wistar大鼠分为正常对照组及DPH（n=20），DPH组灌胃给DPH 0.85 mg·kg^-1·d^-1，正常对照组灌胃同体积的生理盐水，连续给药10 d后，采用Morris水迷宫、跳台行为学实验方法，观察DPH对正常成年大鼠学习、记忆功能的影响。结果：DPH大鼠给药第1-6天达到平台的潜伏期、游程、平均速度、朝向角及第7天大鼠在2 min内的穿越平台的次数、在平台区的逗留时间、平台象限内的逗留时间、平均速度、朝向角及平台区象限内的游程占总游程的百分比，与正常对照组比较差异均无显著性（P〉0.05）；DPH组大鼠第1和2天跳台的错误次数及潜伏期，与正常对照组比较差异均无显著性（P〉0.05）。结论：DPH对正常成年大鼠学习、记忆功能无促进作用。Objective To explore the effects of donepezil hydrochloride on learning and memory function in normal adult rats. Methods According to weight, 40 Wistar rats were randomly divided into 2 groups： normal control group and donepezil hydrochloride group （n= 20）. The learning and memory function in rats were determined with Morris water maze and Step-down tests. Results Compared with control group, latency, distance, average speed and starting angle of rats treated by donepezil hydrochloride did not change significantly from the first day to the sixth day （P〉0.05） ; the time in platform, the time of platform quadrant in 2 minutes, times passing platform, the percentage of distance in platform / total distance and average speed also did not change significantly on the 7th day in Morris water maze test （P〉0.05） ; Error times of rats treated by donepezil hydrochloride did not decrease on the 1st and 2nd day （P〉0.05）, latency did not prolong in the 2nd day in Step-down test （P〉0.05） Conclusion Donepezil hydrochloride do not improve learning and memory function in normal adult rats.

关 键 词：盐酸多奈哌齐 学习 记忆 大鼠 Wistar 

分 类 号：R749.16[医药卫生—神经病学与精神病学] R-332[医药卫生—临床医学]