dl-萘普生重排合成的工艺研究V~Δ  

SYNTHESIS OF dl NAPROXEN BY 1,2 ARYL REARRANGEMENT.V

作　　者：陈芬儿[1] 管春生[1] 户业丽[1] 冯秀梅[1] 谢斌 凌秀红[1] 

机构地区：[1]武汉化工学院合成药物研究中心

出　　处：《中国医药工业杂志》1997年第1期3-5,共3页Chinese Journal of Pharmaceuticals

摘　　要：以２－甲氧基萘为起始原料，经二溴化、脱溴、偶联、缩酮化、重排、水解得ｄｌ－萘普生（１），以２－甲氧基萘计算，总收率为７７％。Methoxynaphthalene was subjected to bromination and debromination in one pot reaction to afford 2 bromo 6 methoxynaphthalene(3)while 5 bromo substituent of 2 was selectively removed by AlCl 3/CH 3NO 2 system.In the presence of a catalytic amount of Fe(acac) 3,the coupling reaction of 6 methoxy 2 naphthylmagnesium bromide with 2 bromopropionyl chloride provided 2 bromo 1 (6 methoxy 2 naphthyl)propan 1 one(4),which was converted to dl naproxen by ketalization,rearrangement,saponification and acidification.The overall yield was 77% from 2 methoxynaphthalene.

关 键 词：萘普生 合成工艺 

分 类 号：TQ463.54[化学工程—制药化工]