蜱抗原免疫接种诱导宿主抵抗力的研究  

Immunization Induce Resistance of Rabbits to Ixodes sinensis Using Tick Antigans

作　　者：刘志刚[1] 叶炳辉[2] 熊国强 崔晓民[1] 

机构地区：[1]江西医学院寄生虫学教研室,南昌330006 [2]南京医科大学寄生虫学教研室 [3]南昌市西湖卫生防疫站

出　　处：《中国人兽共患病杂志》1997年第2期20-22,共3页Chinese Journal of Zoonoses

基　　金：国家自然科学基金;江西省自然科学基金!950001

摘　　要：本文选用中华硬蜱雌性成虫中肠抗原、卵抗原对家免进行人工免疫接种，在按常规方法免疫接种三次后，用中华硬蟀成虫进行感染（叮咬），分别观察中肠抗原接种组、卵抗原接种组、佐剂对照组和空白对照组中华硬蜱的吸血量、生殖情况。结果显示．中华硬蜱叮咬中肠抗原免疫接种兔后其吸血量、产卵量均较对照组显著降低，蜱的吸血量较佐剂和空白对照组分别下降48．56％和54．65％，产卵量下降52.8％和57.9％，而中华硬蜱叮咬卵抗原免疫接种组兔后其吸血、生殖能力较对照组无显著性差异（P＜0．05）。实验表明中华硬碑中肠抗原可有效诱导宿主产生特异性抵抗力，并对该现象进行了分析讨论。In this paper,resistance to adult Ixodes sinensis(♀) was investated in rabbits following lmmunization with extracts derived from midgut antigens and egg antigen.The ticks (Ixodes sinensis) infestated the rabbits after immunized 3 times using conventional method; observed the homatophagia and reproduction of Ixodes sinensis of midgut antigen group.egg antigen group.adjurant group and normal group. The results showed that the engorgement weights and egg productiori of midgut antigen group were declined than control group significantly. Most of ticks cannot attached engorgement and the engorgement weight declined 48. 56 % and 54.65 % and egg production declined 52. 8% and 57. 9%. But Ixodes sinensis infested the rabbits using egg antigens,its homatophophegia and reproduction compere with adjurant and normal group have not significantly(P>0. 05 ). This paper indicate that midgut antigens of Ixodes sinensis may induce rabbfts special resistence to ticks and disscue this phenomenon.

关 键 词：中华硬蜱 免疫接种 

分 类 号：R384.4[医药卫生—医学寄生虫学] S855.9[医药卫生—基础医学]