黄河流域11个地区51个干休所离退休干部认知障碍及老年痴呆危险因素分析  

Analysis of risk factors of cognitive handicap and senile dementia in honorary retired and ordinary retired cadres from 51 cadre sanatoriums of 11 areas in the Yellow River Valley

作　　者：刘吉林[1] 高虎[1] 宋枫[1] 王先华[1] 杨彩[1] 赵治华[1] 

机构地区：[1]解放军兰州军区兰州总医院干部病房,甘肃省兰州市730050

出　　处：《中国组织工程研究与临床康复》2007年第30期5869-5871,共3页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：目的:调查兰州部队辖区黄河流域老年痴呆及认知障碍的患病率并分析其危险因素。方法:应用《长谷川智力量表》(22～30.5分为轻度异常,10.5～21.5分为痴呆前期,≤10分为痴呆期)和《临床记忆量表》(≤80分为异常),对黄河流域11个地区51个干休所16538人群中2944名60岁以上人员进行调查。采用挨家挨户一对一的的方法开展调查检测,只有2个量表评分均为异常才列为病例组,同时对一般情况、驻地海拔高度、家族遗传史、既往病史、生活习惯等5个方面30个危险因素进行调查,并应用SPSS10.0软件包将调查结果进行多元回归分析。结果:2944名受试者全部完成测试进入结果分析。①老年痴呆的患病率分别为痴呆0.71%,痴呆前期2.11%,轻度异常28.46%,总患病率为31.28%。②多元回归分析结果:脑萎缩(t=-6.304)、重大生活事件(t=-5.328)、高龄(t=-5.415)、无喝茶嗜好(t=-3.802)、脑梗死(t=-3.343)、女性(t=-2.604)、冠心病(t=2.496)、低文化程度(t=1.973)、职业(t=1.965)、高海拔地区(t=1.957)与老年痴呆相关(P均<0.05)。结论:①黄河流域老年痴呆及认知障碍发生与脑萎缩、重大生活事件、高龄、无喝茶嗜好、脑梗死、女性、冠心病、低文化程度、职业、高海拔地区等10种危险因素有关。②结果显示痴呆发病率较低,而痴呆前期及轻度异常发病率较高,所以应重视痴呆前期及轻度异常患者的干预治疗。AIM： To investigate the prevalence rate of senile dementia and the cognitive handicap of senile persons in Yellow River Valley of Lanzhou military area command and analyze the risk factor. METHODS： Neuropsychological scale （HDS） （22-30.5 points as mild abnormality, 10.5-21.5 points as in prophase of dementia, ≤ 10 points as in dementia） and clinical memory scale （CMS） （≤80 points as abnormality） were given to the 2 944 subjects aged over 60 years among 16 538 people of the 11 areas of 51 cadre sanatorium in the Yellow River Valley. An investigation was given to the subjects one by one. The persons being diagnosed as having abnormality by the two scales were as case group. At the same time, general conditions, height above sea level, history of family heredity, history of past disease, living habit and so on including 5 aspects and 30 risk factors were surveyed. The result of investigation was analyzed with multiple regression analysis with SPSS 10.0 software. RESULTS： A total of 2 944 testees were involved in the result analysis. （1）The prevalence rate of senile dementia was as following, 0.71% in dementia, 2.11% in pre-dementia, 28.46% in mile dementia, with the total prevalence rate of 31.28%. （2）Result of multiple regression analysis： brain atrophy （t =-6.304）, great life events （t =-5.328 ）, advanced age （ t = - 5.415 ）, no appetite for tea （ t =-3.802 ）, cerebral infarction （ t =-3.343 ）, female （ t =-2.604 ）, coronary heart disease （ t =2.496）, low cultured degree （ t =1.973 ）, profession （ t =1.965 ）, high height above sea level （ t =1.957 ） were associated with senile dementia （P 〈 0.05）. CONCLUSION： （1）The occurrence of senile dementia and cognitive handicap is closely related with the 10 risk factors those are brain atrophy, great life events, advanced age, no appetite for tea, cerebral infarction, female, coronary heart disease, low cultured degree, profession, high height above sea level. （2）It shows that the i

关 键 词：痴呆 老年人 认知障碍 患病率 流行病学 危险因素 

分 类 号：R749.1[医药卫生—神经病学与精神病学]