有自杀行为的单、双相抑郁症患者父母育龄及胎次效应比较  

A comparative study on parental age at delivery and birth order of suicidal behavior in unipolar depression and bipolar depression patients

作　　者：祁曙光[1] 董小惠[1] 张云彪[1] 唐琳[1] 蒋德珍[1] 安宝富[1] 

机构地区：[1]无锡市精神卫生中心精神科,江苏省无锡市214151

出　　处：《中国组织工程研究与临床康复》2007年第30期5939-5941,共3页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：目的:比较有自杀行为的单、双相抑郁症患者间父母育龄及胎次效应的差异。方法:于1983-07/2003-06选择无锡市精神卫生中心门诊和住院符合中国精神疾病分类方案与诊断标准第3版及美国精神障碍诊断和统计手册第4版心境障碍中抑郁发作标准的、无严重躯体疾病或脑器质性疾病的抑郁患者。有自杀行为的单相抑郁症患者家系59例,双相抑郁症患者家系31例。采用自行编制的精神病家系调查表(内容主要包括患者及一级亲属所有成员社会人口学资料、疾病发作特点及次数、自杀情况),由两名主治医师或以上的研究人员对每一家系进行调查,然后再由两名研究人员在互不知情的情况下对每一患者进行再诊断。对所有先症者及一级亲属中有自杀行为者进行面检(面检率>95%);对无自杀行为的一级亲属则进行信函调查(53%)及面检(47%)。已死亡及不能进行面检者的资料由一两名一级亲属提供有关情况填写调查表。用Haldance和Smith法观察有自杀行为的单相抑郁症患者及双相抑郁症患者父母育龄及胎次的效应。结果:符合入组诊断标准者共151例,完成家系调查的共122例,其中纳入分析的单相抑郁症家系59例,双相抑郁症家系31例。①单相抑郁症患者胎次为1的13例,胎次为2的15例,胎次为3的13例,胎次为4的8例,胎次为5的8例,胎次为7的2例;双相抑郁症患者胎次为1的10例,胎次为2的11例,胎次为3的7例,胎次为4的1例,胎次为5的2例,胎次为7的0例。②有自杀行为单相抑郁症患者与父母育龄及胎次的关系非常显著(C=2.4>2,P<0.01,6A>X6A);有自杀行为双相抑郁症患者与父母育龄及胎次无显著关系(C=0.74<2,P>0.05)。结论:单相抑郁症患者父母育龄越大和胎次越高者易发生自杀行为,双相抑郁症患者父母育龄和胎次自杀行为的发生无明显关系。提示适龄婚育对防止单相抑郁症自杀行为的发生具有重要意义AIM： To compare the differences of the parental age at delivery and birth order between the unipolar depression and bipolar depression patients with suicidal behavior. METHODS： All patients with depression who had been diagnosed without senous systemic diseases or organic brain syndrome in accordance with Chinese Classification Mental Disorders, Third Edition （CCMD-3） and Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition （DSM-Ⅳ）, were selected from the outpatients or inpatients of Wuxi Mental Health Center from July 1983 to June 2003, consisting of 59 unipolar depression patients and 31 bipolar depression patients. Self-drafted questionnaire （including such parameters as social demographic data, characters and times of episode, and suicide of patients and their first degree relatives） was surveyed in each family by two attending physicians or more professional psychiatrists. Each of these patients was re-diagnosed by two psychopathists unknown to each other. Face-to-face detection was performed in all the probands and their first degree relatives with suicidal behavior, and the detection rate was over 95%, but letter survey （53%） and face-to-face detection （47%） were used in the probands＇ first degree relatives without suicidal behavior. One or two relatives of the probands who had been dead or could not provide their data through face-to-face detection were asked to fill in the questionnaire about these probands＇ related conditions. Haldance and Smith procedures were used to study the effects of parental age at delivery and birth order in the unipolar depression and bipolar depression with suicidal behavior. RESULTS： A total of 151 patients were enrolled, and 122 ones completed the survey, among them, 59 patients suffering from unipolar depressive disorder with suicidal behavior and 31 patients suffering from bipolar depression with suicidal behavior were collected. （1）The birth order of unipolar depression patients were the first of 13 cases, the second of

关 键 词：抑郁症 自杀 双亲 

分 类 号：R749.3[医药卫生—神经病学与精神病学]