帕罗西汀治疗抑郁症的双盲对照研究  

Paroxetine in the treatment of depression: a double-blind controlled clinical trial compared with amitriptyline.

作　　者：黄雄 许美庭 陆泳[1] 黄杏梅[1] 

机构地区：[1]广州市精神病医院,510370

出　　处：《中国神经精神疾病杂志》1997年第2期93-96,共4页Chinese Journal of Nervous and Mental Diseases

摘　　要：评估帕罗西汀和阿米替林治疗抑郁症病人的临床疗效。　　方法　采用随机、双盲对照的研究方法 ,帕罗西汀组和阿米替林组各 1 6例 ,治疗 6周。　　结果　帕罗西汀与阿米替林疗效相似 ,帕罗西汀的植物神经、心血管、神经系统及其它副作用显著少于阿米替林 ;帕罗西汀主要副作用为轻度口干、便秘。Objective To evaluate the efficacy and side-effects of paroxetine. Methods A double-blind controlled trial was designed for comparing paroxetine with amitriptyline to treat depression. Thirty-two inpatients with depression were randomly assigned to take paroxetine (n=16) or amitriptyline (n=16) for six weeks. The efficacy and side-effects were evaluated by Hamilton Depression Scale(HAMD), clinical Global Impression( CGI), Hamilton Anxiety Scale (HAMA) and Treatment Emergent Symptoms Scale (TESS) before treatment and weekly during therapy. Results There was no significant difference in recovery ratio and reduction of scores of HAMD, HAMA and CGI between paroxitine and amitriptyline group. There were much less cardiovascular, nervous system, vegetative nervous system and other side-effects in paroxetine than in amitriptyline group. The main side-effects of paroxetine were slight dry mouth and constipation. Conclusions The results showed that paroxetine was a safe and effective antidepressant drug.

关 键 词：抑郁症 帕罗西汀 阿米替林 

分 类 号：R749.405[医药卫生—神经病学与精神病学]