维生素B_(12)混合液治疗乳腺癌术后放疗急性放射性皮肤损伤初步观察  

Treatment of vitamin B_(12) mixture on radiation induced acute skin injury postoperation of breast cancer

作　　者：鞠云鹤[1] 杨毅[1] 吴星娆[1] 侯宇[1] 

机构地区：[1]云南省肿瘤医院,云南昆明650118

出　　处：《现代肿瘤医学》2007年第7期934-935,共2页Journal of Modern Oncology

摘　　要：目的:探讨乳腺癌术后放疗患者急性放射性皮肤损伤的防治方法。方法:对2004年10月～2005年12月我院86例乳腺癌术后放疗患者出现I级放射性皮肤损伤出现滤泡样暗色红斑/出汗减少时(一般DT30GY/3W)即进行配对分组治疗,实验组用维生素B12混合液(VitB12500μg×20支+0.9%生理盐水250ml+庆大霉素48万U+地塞米松20mg)纱布浸湿外敷,15～20分钟/次,2～3次/日,7天为1疗程,连用2个疗程;对照组单用康复新液湿敷,用法疗程同上。结果:放射治疗结束时皮肤损伤实验组:I级62.79%(27/43);II级27.91%(12/43);III级9.30%(4/43);IV级0(0/43)。对照组皮肤损伤:I级18.60%(8/43);II级55.81%(24/43);III级20.93%(9/43);IV级4.65%(2/43)。两组差异非常显著性,(P<0.01)。结论:乳腺癌术后放疗患者急性放射性皮肤损伤重在早期预防和治疗,维生素B12混合液湿敷是治疗急性放射性皮肤损伤的一种既经济又有效的方法。Objective：To evaluate the efficacy of vitamin B12 mixture on radiation induced acute skin injury after radical or modified radical mastectomy for breast cancer. Methods： From 2004 to 2005,86 patients with breast cancer after radical operation were treated with radiotherapy. On radiation induced acute skin injury , half of the patients were treated with vitamin B12 mixture, others treated with Kanfuxin liquid. Results： Categorization about radiation induced acute skin injury, treatment with vitamin B12 mixture ： degree Ⅰ 62. 79% ; degree Ⅱ27.91% ; degreeⅢ 9. 30% ; degreeⅣ 0, treatment with Kanfuxin liquid： degree Ⅰ 18.60%; degree Ⅱ 55.81%; degreeⅢ 20.93%; degreeⅣ 4.65%. The results of treatment with vitamin B12 mixture was better than with that Kanfuxin liquid （P 〈 0.01 ）. Conclusion： The important way to the patients with acute skin injury after radiotherapy in breast cancer was prevention and treatment earlier. It was an efficient and economic way to treat acute skin injury after radiotherapy in breast cancer with vitamin B12 mixture.

关 键 词：维生素B混合液 乳腺癌 放射性皮肤损伤 防治 

分 类 号：R737.9[医药卫生—肿瘤]