草酸铂联合氟尿嘧啶、甲酰四氢叶酸治疗晚期大肠癌52例临床观察  

Observation on oxaliplatin and LV/5-FU in the treatment of advanced colorectal cancer

作　　者：程梅莲[1] 顾汉刚[1] 朱小霞[1] 

机构地区：[1]江苏大学附属医院肿瘤中心,江苏镇江212001

出　　处：《现代肿瘤医学》2007年第7期968-970,共3页Journal of Modern Oncology

摘　　要：目的:观察草酸铂联合氟尿嘧啶、甲酰四氢叶酸治疗晚期大肠癌的客观疗效及其不良反应。方法:草酸铂(L-OHP)100mg/m2静滴h0～h2,d1;甲酰四氢叶酸钙(CF)200mg/m2静滴h0～h2,d1～2;5-氟尿嘧啶(5-Fu)400mg/m2静冲h2,d1～2;5-Fu600mg/m2持续灌注h2～h24,d1～2。该方案每2周为1周期,2周期为1疗程。用足2疗程者给予疗效评定,所有病人均接受4个周期以上化疗。结果:经该方案治疗的52例晚期大肠癌患者中,CR4例,PR21例,SD19例,PD8例,总有效率48.1%,中位缓解期为6.7个月,中位生存期为10.5个月,1年生存率38.2%。主要不良反应有恶心、呕吐、黏膜炎、外周神经炎等。不良反应多为Ⅰ～Ⅱ度,病人耐受良好。结论:应用该方案治疗晚期大肠癌疗效确切,不良反应轻微,值得临床推广使用。Objective： To observe the efficacy and toxicity of oxaliplatin combined with LV/5FU in the treatment of advanced colctal cancer. Methods ： Fifty two patients with advanced colorectal cancer were treated with Oxaliplatin plus 5 -FU/CF regimen, which consisted of oxaliplatin 100mg/m^2 on day 1, CF 200 mg/m^2 as a 2h infusion fol- lowed by bolus 5 - FU 400 mg/m^2 and a 22h infusion of 5 - FU 600 mg/m^2 , repeated for 2 consecutive days every 2 weeks at least 4 courses. All patients were assessable for toxicity and response to treatment. Results： Four （7.7%） complete responses and 21 partial responses were observed （overall response rate 48.1% ）. Stable disease was observed in 19 （36.5%） patients, with progressive disease in the other eight （15.4%） patients. Median time to progression （TTP） and median overall survival （OS） were 6.7 and 10.5 months respectively. The one year survival rate was 38.2%. The most common toxicities were grade 1 - 2 nausea, emesis, mucositis, peripheral neuritis etc. Conclusion： The regimen which we useed in this study to treat advanced colctal cancer is effective and well -tolerated. So it is worthy to be further studied and popularized.

关 键 词：草酸铂 氟尿嘧啶 甲酰四氢叶酸 晚期大肠癌 化疗 

分 类 号：R735.34[医药卫生—肿瘤]