羟基喜树碱联合IL-2治疗恶性腹腔积液的疗效观察  

Efficacy of combined HCPT with IL-2 in the treatment of malignant ascites of abdominal cavity

作　　者：董灵[1] 赵全德[1] 李向东[1] 宋怡兵[1] 黄小玲[1] 

机构地区：[1]四川省阆中市人民医院肿瘤科,四川阆中637400

出　　处：《现代肿瘤医学》2007年第7期974-975,共2页Journal of Modern Oncology

摘　　要：目的:观察羟基喜树碱(HCPT)联合重组人白介素-2(IL-2)治疗恶性腹腔积液的疗效。方法:将24例恶性腹腔积液的患者置管放净腹水后,经导管注入NS40ml+HCTP20mg,NS40ml+IL-2100万单位,每周1～2次,观察总有效率及毒副反应。结果:24例患者总有效率为95.9%,腹痛4.1%,骨髓抑制发生率70.8%,均为Ⅰ°～Ⅱ°,发热8.3%,脱发100%,恶心75%,无呕吐,未见心电图及肝肾功能异常。结论:羟基喜树碱联合IL-2治疗恶性腹腔积液疗效好,副反应轻,值得推广。Objective： Combine HCPT with IL -2 to cure malignant ascites of abdominal cavity and observe the curative effect. Methods： To put tubes into the abdomen of 24 patients with malignant ascites of abdominal cavity and absord the water completely,then inject NS40ml ＋ HCPT 20 mg NS40ml ＋ IL - 2 100u. Results： In the 24 patients,the total effetiverate was 95.9% ;bellyache 4.1% , the occurrence of marrow inhibiting rate was 70.8% , falling of air：100% ,nausea：75% ,liver and kidney function were normal. Conclusion： Combine HCPT with IL -2 to cure malignait precipitate of abdominal cavity can get a good curative effects.

关 键 词：恶性腹腔积液 羟基喜树碱 重组人白介素-2 

分 类 号：R735.5[医药卫生—肿瘤]