抗肿瘤血管生成治疗相关性研究  

Some relative research in gene therapy for antiangiogegsis

作　　者：张宁宁[1] 刘文超[1] 薛妍[1] 

机构地区：[1]第四军医大学西京医院肿瘤科,陕西西安710032

出　　处：《现代肿瘤医学》2007年第7期1010-1012,共3页Journal of Modern Oncology

基　　金：国家自然科学基金(30572100);陕西省自然科学研究项目基金(2004C222)

摘　　要：血管生成是肿瘤生长、侵袭、转移、和复发的基础。肿瘤血管生成是诸多因素共同作用的结果,其中血管生长刺激因子和血管生长抑制因子作用平衡与否,决定了血管生成是促进还是抑制。抗血管生成作为肿瘤治疗新方法,已成为重要的抗肿瘤策略。基因治疗则使抗血管生成治疗更具有靶向性。本文就该领域研究情况作一综述。Angiogenesis is the basis of tumor growth, invasion, metastasis and recidivism. Tumor angiogenesis results from multiple factors, and the imbalance of angiogenic cytokines and angiogenesis inhibitors determine to facilitate or inhibit angiogenesis. As a new field of cancer therapy, tumor antiangiogenesis therapy has become an important anti -tumor strategy. Gene therapies make the antiangiogenesis therapy become more special. This article reviews the current research of tumor angiogenesis, with a focus on gene therapy in this field.

关 键 词：肿瘤 血管生成 基因治疗 

分 类 号：R730.5[医药卫生—肿瘤]