阻塞性黄疸病人淋巴细胞膜高、低亲和力白细胞介素-2受体的变化  被引量:2

Changes of lymphocyte high and low affinitymembranous interleukin-2 receptor expression in pa-tients with obstructive jaundice

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作  者:林守诚[1] 王炳生[1] 孟承伟 

机构地区:[1]解放军117医院普外科,上海医科大学附属中山医院外科

出  处:《中华实验外科杂志》1997年第2期75-76,共2页Chinese Journal of Experimental Surgery

摘  要:为了解阻塞性黄疸病人的细胞免疫状态,我们用放射性配基结合分析法测定53例阻塞性黄疸病人胆道引流前后淋巴细胞膜白细胞介素-2受体(IL-2R)的表达。病人按疾病的良、恶性分为两组。结果:①高亲和力IL-2R位点数良、恶性两组都低于对照组。胆道引流21天后,良性组恢复正常,恶性组虽比引流前有明显提高,却仍低于对照组,胆道引流42天后恶性组进一步提高,但仍未达到正常水平;②低亲和力IL-2R位点数在胆道引流前后无变化,但恶性组都低于对照组和良性组。③在恶性组,胆道的内外引流对淋巴细胞膜高亲和力IL-2R表达的恢复无明显影响。结论:阻塞性黄疸可抑制淋巴细胞膜形成高亲和力IL-2R的能力,恶性肿瘤的存在可增强该抑制作用;胆道引流后这种抑制作用基本恢复,而恶性肿瘤的抑制作用是不能恢复的。A rqdioligand binding assay(RBA)wasdeveloped to detect lymphocyte expression of high andlow affinity membranous interleukin 2 receptor(IL-2R)in 53 patients with obstructive jaudice undergoing biliaarydrainage.The patients were divided into two groups ac-cording to benignancy or malignancy of the underlyingdiseases.The high affinity IL-2R expression of bothgroupswas significantly reduced comparing with the con-trol group.21 days after biliary drainage,the high affini-ty IL-2R expression of benign group returned to nor-mal,while in malignant group it was still lower than thatof normal controls,although markedly elevated than be-fore drainage.42 days later it continued to elevated,butwas lower than that of control group.However,no dif-ference was found in the low affinity IL-2R expressionbefore and after drainage,though its number of the ma-lignant group is lower than that of the benign and con-trol groups.In malignant group,internal or externaldrainage did not influence the recorvery of high affinityIL-2R expression.

关 键 词:阻塞性黄疸 白细胞介素 淋巴细胞 细胞膜 

分 类 号:R575.03[医药卫生—消化系统]

 

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