类风湿关节炎患者肺功能变化与CR1、CD59表达水平的关系  

Changes of Pulmonary Function in Patients with Rheumatoid Arthritis and Correlation Study between Them and CR1 and CD59

作　　者：刘健[1] 范海霞[1] 杨梅云[1] 

机构地区：[1]安徽中医学院第一附属医院,安徽合肥230031

出　　处：《中国临床医学》2007年第3期306-309,共4页Chinese Journal of Clinical Medicine

基　　金：国家中医药管理局专项课题(04-05LP27);安徽省自然科学基金项目(050431002)

摘　　要：目的:观察类风湿关节炎(rheumatoid arthritis,RA)患者肺功能的变化及其与CR1、CD59及其他指标之间的关系。方法:测定80例患者的肺功能,与正常对照组进行比较,并将其与CR1、CD59及其他指标(年龄、病程、症状积分、生活质量积分及实验室指标)进行相关性分析。结果:RA组深吸气量(IC)、最大通气量(MVV)、用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、25%肺活量位的最大呼气流量(FEF25)、50%肺活量位的最大呼气流量(FEF50)、75%肺活量位的最大呼气流量(FEF75)和最大呼气流量(PEF)均明显低于健康对照组(P<0.05或P<0.01)。相关分析发现,IC与C3呈正相关(P<0.05),MVV与年龄、15m步行时间、α1-AGP、CRP、ESR呈负相关(P<0.05),FVC与15 m步行时间、IgA,C4,α1-AGP,CRP呈负相关(P<0.05),FEV1与关节疼痛积分、生理功能积分、IgA、C4、α1-AGP、CRP呈负相关(P<0.05),FEV1/FVC与病程、关节肿胀积分、RF呈负相关(P<0.05),FEF25与年龄、关节肿胀积分、15 m步行时间、生理功能积分、CRP呈负相关(P<0.05),FEF50与年龄、关节疼痛积分、15 m步行时间、生理功能积分、C4、CRP、ESR呈负相关(P<0.05),与CR1、CD59成正相关(P<0.05),FEF75与关节疼痛积分、15 m步行时间、RF、α1-AGP、CRP、ESR呈负相关(P<0.05),与CD59成正相关(P<0.05),PEF与关节疼痛积分、15 m步行时间、生理功能积分、CRP呈负相关(P<0.05)。结论:RA患者的肺功能与健康人相比有多个参数显著降低,肺功能改变以通气功能障碍为主,其次为较高比例的小气道阻塞,并可见肺容积减小,而且肺功能的改变与CR1、CD59表达水平的降低、补体系统异常活化相关,与病情及疾病活动性亦密切相关。Objective： To observe the changes of pulmonary function and the relations among them and CR1,CD59 and other index. Methods：Pulmonary function in 80 patients with rheumatoid arthritis were determined and compared with normal control group. The correlation between pulmonary function and CR1,CD59 and other index（age, course of disease, accumulate points of symptoms, accumulate points of life quality and index of experiment） were analyzed. Results： IC, MVV, FVC, FEV1, FEF25, FEF50, FEF75, PEF of patients with rheumatoid arthritis were lower than those of normal control group（P〈0. 05）. Correlation analysis showed that there was a positive correlation between IC and C3 （P〈0. 05）. There were negative correlations between MVV and age, time of walking 15m,α1-AGP,CRP and ESR （P〈0.05）. There were negative correlations between FVC and time of walking 15m, IgA,C4,α1-AGP and CRP （P〈0. 05）. There were negative correlations between FEV1 and accumulate points of joint pain, accumulate points of physiological function, IgA, C4, α1-AGP, CRP （P〈0.05）. There were negative correlations between FEV1/FVC and course of disease, accumulate points of joint swelling, RF （P〈0.05）. There were negative correlations between FEF25 and age, accumulate points of joint swelling, time of walking 15m, accumulate points of physiological function and CRP （P〈0.05）. There were negative correlations between FEF50 and age, accumulate points of joint pain, time of walking 15m, accumulate points of physiological function, C4,CRP and ESR （P〈0. 05）. And there were positive correlations between FEF50 and CR1 and CD59. There were negative correlations between FEF75 and accumulate points of joint pain, time of walking 15m, RF, α1-AGP, CRP and ESR （P〈0.05）. And there were positive correlations between FEF75 and CD59. There were negative correlations between PEF and accumulate points of joint pain, time of walking 15m, accumulate points of physiological function and CRP （P〈0.05）. Conclusion�

关 键 词：类风湿关节炎 肺功能 CR1 CD59 

分 类 号：R593.22[医药卫生—内科学]