support from the National Natural Science Foundation of China(22121003,22337006,32027901 and 21927814);the National Key R&D Program of China(2019YFA0904201,2023YFA0916300,2021YFA0910202 and 2022YFA1304701);the Strategic Priority Research Program of Chinese Academy of Sciences(XDB37040203);the CAS Project for Young Scientists in Basic Research(YSBR-015 and YSBR-072-6).
Dear Editor,Succinate(SA)is a classic intermediate metabolite of the TCA cycle and is produced in mitochondria under normal physiological conditions.1 SA accumulates within cells and is secreted into the extracellular...
supported by grants from CAS Strategic Priority Research Program(XDB37030103 to H.E.X.);Shanghai Municipal Science and Technology Major Project(2019SHZDZX02 to H.E.X.);Shanghai Municipal Science and Technology Major Project(H.E.X.);the National Natural Science Foundation of China(32130022,82121005);the Lingang Laboratory(LG-GG-202204-01 to H.E.X.);the National Key R&D Program of China(2022YFC2703105 to H.E.X.)。
Dear Editor,Succinic acid,once considered merely a tricarboxylic acid cycle intermediate,1 has been recognized for its significant role in influencing mitochondrial reactive oxygen species homeostasis.2 This is largel...
supported by the National Key Research and Development Program of China(2022YFC2502600,2022YFC2502606);the National Natural Science Foundation of China(82170206,82170208);the CAMS Innovation Fund for Medical Sciences(2019-I2M-5-034,2022-I2M-C&T-B-121);Peking University People’s Hospital Research and Development Funds(RZ2022-02);National High Level Hospital Clinical Research Funding(BJ-2022-169);ShanghaiMunicipal Health Commission Project of Disciplines of Excellence(20234Z0002).
Acutemyeloid leukemia(AML),which is the most common form of acute leukemia in adults,is a heterogeneous,clonal hematopoietic disorder characterized by the accumulation of immature myeloid progenitors.This heterogeneit...