Molecular activation and G protein coupling selectivity of human succinate receptor SUCR1  

作　　者：Tianxin Wang Wenqin Tang Xiaolei Zhu Zhenyu Lv Jiayan Chen Yongze Li Xiaoyu Sun Haoyu Lv Quanchang Gu Fahui Li Jiangyun Wang 

机构地区：[1]iHuman Institute,ShanghaiTech University,Shanghai,China [2]School of Life Science and Technology,ShanghaiTech University,Shanghai,China [3]Institute of Biophysics,Chinese Academy of Sciences,Beijing,China [4]School of Life Sciences,University of Chinese Academy of Sciences,Beijing,China [5]Key Laboratory of Biomacromolecules,Chinese Academy of Sciences,Beijing,China

出　　处：《Cell Research》2024年第8期590-593,共4页细胞研究（英文版）

基　　金：support from the National Natural Science Foundation of China(22121003,22337006,32027901 and 21927814);the National Key R&D Program of China(2019YFA0904201,2023YFA0916300,2021YFA0910202 and 2022YFA1304701);the Strategic Priority Research Program of Chinese Academy of Sciences(XDB37040203);the CAS Project for Young Scientists in Basic Research(YSBR-015 and YSBR-072-6).

摘　　要：Dear Editor,Succinate(SA)is a classic intermediate metabolite of the TCA cycle and is produced in mitochondria under normal physiological conditions.1 SA accumulates within cells and is secreted into the extracellular space,engaging in metabolic regulation and inflammatory response during conditions such as hypoxia,ischemia-reperfusion,and pro-inflammatory processes.2 Excess SA functions as a paracrine signal through its extracellular G protein-coupled receptor,SUCR1,3 which senses extracellular metabolic stress signals and regulates energy homeostasis.4 SUCR1 couples to Gi and Gq signaling pathways,5 resulting in physiological effects closely tied to human health and diseases such as hypertension,diabetes,inflammation,atherosclerosis,sepsis,immune response,cancer,asthma,and adiposity.

关 键 词：CR1 HOMEOSTASIS INFLAMMATION 

分 类 号：Q51[生物学—生物化学]