胃肠道间质瘤32例临床病理分析  

Analysis of the Clinicopathology on 32 Gastrointestinal Stromal Tumors

作　　者：魏民 

机构地区：[1]河南省中原油田总医院病理科,河南濮阳457001

出　　处：《中国临床医学》2007年第3期428-430,共3页Chinese Journal of Clinical Medicine

摘　　要：目的:探讨胃肠道间质瘤(GIST)的组织病理形态学和免疫组织化学特点。方法:用CD117、CD34、SMA、Desmin、S-100蛋白质抗体通过免疫组织化学SP法对原发性GIST进行研究。结果:本组GIST主要发生在胃(65.6%),常以上消化道出血为首发症状。肿瘤基本组织形态为梭形细胞和上皮样细胞。免疫组化染色CD117和CD34阳性率分别为90.6%和81.3%。结论:GIST好发生在中老年,肿瘤细胞形态多变和排列方式多样,免疫组织化学染色为CD117、CD34阳性、Desmin阴性,S- 100蛋白和SMA不表达或者呈灶状阳性,肿瘤细胞直径≥5 cm,核分裂像大于5个/50 HP可作为恶性参考指标。Objective：To explore the histopathological and immunohistochemical feature of astrointestinal tumors. Methods： Immunohistochemical staining were performed in the primary gastrointestinal tumors for a panel of antibodies such as CD117, CD34, SMA, Desmin, S-100 by SP methods. Results：The tumors mainly were located in the stomach （65.6 %）. The primary cell morphology consisted of spindle shaped cells and epithelioid cells. Immunohistochemically, the positive rates of CDl17 and CD34 were 90.6%and 81.3% respectively. Conclusion： GISTs predominantly occurred in middle aged or older patients, with various kinds of cell types and different arrangements. Immunohistochemical staining was positive for CD117 and CD34, negative for desmin, focal positive or absent for S-100 protein and SMA. The tumors are over or equal 5 cm in diameter, mitotic count is over 5 / 50 HP might help to identify tumors with malignant potential.

关 键 词：胃肠道间质瘤 免疫组织化学 组织病理形态学 

分 类 号：R735[医药卫生—肿瘤]