沙棘籽渣黄酮和沙棘油对高糖高脂诱导的老年肥胖雌鼠血脂的影响  

EFFECT OF FLAVONOIDS FROM SEED RESIDUES AND OIL OF HIPPOPHAE RHAMNOIDES L.ON SERUM LIPID OF FEMALE AGED RATS WITH OBESITY

作　　者：杨现艳[1] 瞿伟菁[1] 徐自良[2] 邵国民[2] 张雯[1] 杨益欣[1] 

机构地区：[1]华东师范大学生命科学学院,上海200062 [2]浙江省中医院,杭州310006

出　　处：《营养学报》2007年第3期284-287,共4页Acta Nutrimenta Sinica

基　　金：上海市科技发展基金项目(No.014358009)

摘　　要：目的:观察沙棘籽渣黄酮和沙棘油对老年肥胖雌鼠血脂的影响。方法:应用沙棘籽渣黄酮和沙棘油对高糖高脂诱导的老年肥胖雌鼠进行灌胃给药,连续6w,观察对老年肥胖雌鼠体重、肥胖指数、血脂及游离脂肪酸、高低密度脂蛋白等指标的影响。结果:沙棘籽渣黄酮可显著降低老年肥胖雌鼠的肥胖指数,有效控制其体重增加;并能极显著降低模型动物血清甘油三酯和游离脂肪酸水平;沙棘油可显著降低老年肥胖雌鼠的游离脂肪酸水平。结论:沙棘籽渣黄酮和沙棘油均可显著改善老年肥胖雌鼠血脂状况。Objective： To study the effect of flavonoids from seed residues of Hippophae rharnnoides L.（FSH） and Hippophae rharnnoides L. oil （HRO） on serum lipid in female rats with obesity. Methods Female aged rats with obesity were given FSH and HRO by oral administration for 6 w. Serum triglyceride（TG） and cholesterol（TC） were determined every 2 w. The serum free fatty acid （FFA）, high- density lipoprotein cholesterol （HDL-C）, body weight and Lee＇s index were measured after 6 w. Results： Serum TG and FFA level decreased significantly in rats given FSH. At the same time, FSH could inhibit the increase in body weight and Lee＇s index. HRO could regulate the lipid metabolism and decrease serum TG level significantly in female aged rats with obesity. Conclusion： Both FSH and HRO can improve lipid metabolism in female aged rats with obesity.

关 键 词：沙棘籽渣黄酮 沙棘油 血脂 老年肥胖雌鼠 

分 类 号：R285.5[医药卫生—中药学]