低剂量磷酸雌二醇氮芥在前列腺癌治疗中的应用  

The application of low-dose EMP in the treatment of prostate cancer

作　　者：魏武[1] 葛京平[1] 马宏青[1] 张征宇[1] 高建平[1] 

机构地区：[1]南京军区南京总医院泌尿外科,南京210002

出　　处：《临床肿瘤学杂志》2007年第6期432-434,共3页Chinese Clinical Oncology

摘　　要：目的:探讨雌二醇氮芥在前列腺癌治疗中的有效应用剂量。方法:回顾性分析低剂量磷酸雌二醇氮芥(EMP)在前列腺癌患者中的应用情况,对服用EMP280mg、2次/天及140mg、2次/天不同剂量下85例前列腺癌患者出现的胃肠道反应及肝功损害的情况进行分析,并比较两种剂量下前列腺癌患者的生存时间。结果:在小剂量EMP治疗时,肝功损害的发生显著减少,而胃肠道反应无明显变化。两种剂量对前列腺癌生存时间无明显差异(P>0.05)。结论:减少EMP剂量可降低该药肝功损害的发生,而对前列腺癌治疗效果无明显影响。Objective： To explore the effective application of EMP in the treatment of prostate cancer. Methods ： We retrospectively analysed the clinical data of patients who accepted with low-dose EMP, The occurrences of the gastrointestinal discomfort and hepatic dysfunoction were observed in the patients who used the EMP at doses of 280mg and 140mg two times a day, respectively. Kaplan-Meier method was employed to investigate the impact of EMP doses on survival time. Results：The occurrence of hepatic dysfunction decreased signifcantly and occurrence of gastrointestinal discomfort had no significant change in patients with low-dose EMP. There was no significant difference in survival time between those patients with different doses of EMP. Conclusion：We can decrease the occurrence of hepatic dysfunction and do not impact the patient＇s survival time by reducing the dosage of EMP.

关 键 词：前列腺癌 磷酸雌二醇氮芥 

分 类 号：R737.25[医药卫生—肿瘤] R730.53[医药卫生—临床医学]