慢性肝病患者血液、腹水TNF-α、IL-6、IL-10的检测分析  

To analyze the TNF-α,IL-6,IL-10 in blood and ascites of patient with chronic liver diseases

作　　者：刘伟[1] 吴引伟[1] 刘新钰[1] 

机构地区：[1]东南大学医学院附属南京第二医院肝病检测中心,江苏南京210003

出　　处：《中西医结合肝病杂志》2007年第3期169-170,共2页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

摘　　要：目的:观察慢性肝病患者血液、腹水TNF-α、IL-6、IL-10的变化特点。方法:随机选择50例慢性肝炎、40例肝炎肝硬化,14例慢性重型肝炎,用流式细胞仪检测其血液、腹水TNF-α、IL-6、IL-10。结果:慢性肝病患者血液TNF-α、IL-6、IL-10水平,从慢性肝炎到肝炎肝硬化再到慢性重型肝炎,呈递增趋势,彼此间比较,差异有显著性意义(P<0.05);腹腔感染组与无感染组患者血液TNF-α、IL-6、IL-10比较,差异均有显著性意义(P<0.05)。腹腔感染组与无感染组患者腹水TNF-α、IL-6、IL-10比较,其差异均无显著性意义(P>0.05)。结论:慢性肝病患者血液TNF-α、IL-6、IL-10与其病程进展和合并腹腔感染有关。Objective： To study the changing feature of tumor necrosis factor-alpha （TNF-α）, interleukin-6 （IL-6）, interleukin-10 （IL-10） in blood and ascites of patients with chronic liver diseases. Methods： Fifty cases patients with chronic hepatitis （CH） and 40 cases patients with liver cirrhosis （LC） or 14 cases patients with chronic severe hepatitis （CSH） elected by a random methods were detected the TNF-α, IL-6, IL-10 in blood and ascites by the flow cytometry technique. Results： For the levels of TNF-α, IL-6, IL-10 in blood and ascites, from CH to LC and to CSH, it was increase, the difference among them was significant （P 〈0. 01 ）. For the levels of TNF-α, IL-6, IL-10 in blood and ascites in the group with abdominal cavity infection and the group free from infection, the difference between the two group in blood was significant （P 〈 0. 01 ）, the difference between the two group in ascites wasn＇t significant （P 〉0. 05）. Conclusion： The TNF-α, IL-6, IL-10 in blood of patients with chronic liver diseases was related with their course of disease developing and abdominal cavity infection occurring.

关 键 词：肝病 慢性 肿瘤坏死因子 白细胞介素-6 白细胞介素-10 

分 类 号：R575[医药卫生—消化系统] R446.6[医药卫生—内科学]