儿童青少年卵巢恶性肿瘤临床特点及治疗探讨—25年48例临床资料回顾性分析  

CLINICAL ANALYSIS OF OVARIAN MALIGNANT TUMOR IN CHILDREN AND ADOLESCENTS:RETROSPECTIVE STUDY OF 48 CASES DURING 25 YEARS

作　　者：王彤[1] 孔为民[1] 段薇[1] 

机构地区：[1]首都医科大学附属妇产医院妇瘤科,北京100006

出　　处：《现代预防医学》2007年第13期2584-2586,共3页Modern Preventive Medicine

摘　　要：[目的]探讨儿童青少年卵巢恶性肿瘤临床诊断治疗特点及预后相关因素。[方法]收集我院1980年8月～2005年12月25年间收治的48例18岁以下的卵巢恶性肿瘤患儿的临床资料,按生殖细胞肿瘤、性索间质肿瘤、上皮性肿瘤分为3组,统计分析年龄、病理类型、症状、分期、手术方式、化疗方案、随访结果。[结果]发病年龄4～18岁。恶性生殖细胞肿瘤最多发,共32例,占66.7%。腹部包块、腹痛、腹胀是位居前3位的主要症状。大多数是Ⅰ～Ⅱ期早期病例,共39例,占81%。5年生存率保留生育功能手术患者是72.8%,肿瘤细胞减灭术患者是76.2%,二者差异无统计学意义。分期和病理类型是影响生存率的主要因素。[结论]建议各科医师提高对此类疾病认识,青春期少女应重视体检,尽早发现肿瘤。Ⅰ～Ⅱ期早期病例,可以行保留生育功能手术,术后辅以化疗。儿童青少年卵巢恶性肿瘤有较高的5年生存率。[ Objective] To determine the serum levels of anti-sperm antibody （AsAb） and tamour necrosis factor α （TNF-α） in infertility patients, in order to explore the function of AsAb and TNF-α in infertility. [Methods] The levels of AsAb and TNF-α in serum samples of 46 cases and 40 normal controls were determined by ELISA. [ Results] The positive rate of serum AsAb in infertility patients was 30.43%. which was significantly higher than that of the normal control group （5%） （P〈 0.05） . The serum TNF-α level in infertility women was 168±15 ng/L. which was obviously higher than that of the normal control group （145±14 ng/L）（P 〈 0.01 ） . The serum TNF-α level in AsAb positive group was significantly higher than that of AsAb negative group （ 177±16 ng/L vs 160±15 ng/L. P 〈 0.01 ） . The serum TNF-α level had positive con＇elation with serum AsAb level （r = 0.778, P 〈 0.01 ） . [ Conclusion] AsAb, TNF-α are important immune factors in infertility, the high level of TNF-α in serum tins close relation to AsAb positive m serum of infertility patients.

关 键 词：卵巢肿瘤 恶性 儿童 青少年 诊断 治疗 

分 类 号：R737.31[医药卫生—肿瘤]