116例腮腺粘液表皮样癌患者的预后因素分析  

Prognostic Analysis of 116 Patients with Mucoepidermoid Carcinoma of the Parotid Gland

作　　者：卢增红[1] 杨安奎[1] 陈志兴[1] 宋明[1] 魏茂文[1] 

机构地区：[1]华南肿瘤学国家重点实验室

出　　处：《癌症》2007年第7期752-755,共4页Chinese Journal of Cancer

摘　　要：背景与目的:粘液表皮样癌是涎腺中最常见的恶性肿瘤,有关腮腺的粘液表皮样癌的大宗病例报道较少。本研究旨在探讨影响腮腺粘液表皮样癌患者预后的临床病理因素。方法:回顾性分析中山大学肿瘤防治中心1980年5月至2000年12月收治的116例腮腺粘液表皮样癌患者的临床资料,对其预后进行单因素和多因素分析。结果:116例腮腺粘液表皮样癌患者的5、10和15年生存率分别为75.64%、64.55%和60.39%。单因素生存分析显示年龄、饮酒及T分期等12项因素是腮腺粘液表皮样癌预后的影响因素。多因素分析表明T分期(P=0.006,OR>1)、病理分级(P=0.000,OR>1)、远处转移(P=0.000,OR>1)是影响腮腺粘液表皮样癌患者预后的独立因素。结论:T分期、病理分级和远处转移是影响腮腺粘液表皮样癌患者预后的独立危险因素。BACKGROUND ＆ OBJECTIVE. Mucoepidermoid carcinoma is the most common malignant tumor of the salivary, but mucoepidermoid carcinoma of the parotid gland has seldom been reported. This study was to summarize the clinicopathologic prognostic factors of mucoepidermoid carcinoma of the parotid gland. METHODS. Clinical data of 116 patients with mucoepidermoid carcinoma of the parotid gland, treated in Cancer Center of Sun Yat-sen University from May 1980 to Dec. 2000, were analyzed with Cox univariate and multivariate models. RESULTS. The overall 5-, 10-, and 15- year survival rates of the 116 patients were 75.64%, 64.55%, and 60.39%, respectively. Univariate survival analysis showed that 12 factors were prognostic factors of mucoepidermoid carcinoma of the parotid gland, such as age, alcohol drinking, T stage, and so on. Multivariate analysis showed that T stage （P = 0.006, OR 〉 1）, pathologic grade （P 〈 0.001, OR 〉 1）, and distant metastasis （P 〈 0.001, OR 〉 1） were independent prognostic factors of mucoepidermoid carcinoma of the parotid gland. CONCLUSION, T stage, pathologic grade and distant metastasis are independent prognostic factors of mucoepidermoid carcinoma of the parotid gland.

关 键 词：腮腺肿瘤 粘液表皮样癌 单因素分析 多因素分析 预后 

分 类 号：R739.8[医药卫生—肿瘤]