消化系癌症手术前后的血清可溶性肿瘤坏死因子受体Ⅰ的变化和意义  

Changes and significance of serum soluble tumor necrosis factor receptor-I levels in patients with cancer of digestive tract

作　　者：吴晴[1] 陈栋晖[1] 周小寒[1] 王裕发[2] 巫协宁[2] 贺玉龙[3] 陈世福[3] 花天放[3] 郑淼[3] 徐传德[3] 

机构地区：[1]上海市第一人民医院肿瘤科,上海200080 [2]上海市第一人民医院中心实验室,上海200080 [3]上海市第一人民医院普外科,上海200080

出　　处：《癌症》1997年第1期45-47,共3页Chinese Journal of Cancer

摘　　要：用双抗体夹心 ELISA 方法测定了60例消化系癌症患者血清可溶性肿瘤坏死因子受体Ⅰ(sTNFR-Ⅰ)的水平。结果表明:消化系癌症患者血清 sTNFR-Ⅰ水平均明显高于正常人(P<0.01),且血清sTNFR-Ⅰ水平与临床分期有关;手术切除肿瘤后,血清 sTNFR-Ⅰ水平明显下降(P<0.01),术后2～8月,16例无癌患者血清 sTNFR-Ⅰ水平继续下降;另32例局部未控制伴复发转移患者血清 sTNFR-Ⅰ水平上升。提示:血清 sTNFR-Ⅰ测定对消化系癌症患者的诊断、疗效及预后的判断均具有重要意义。The levels of serum soluble tumor necrois factor receptor-Ⅰ(sTNFR-Ⅰ) in 60 pa- tients with cancer of digestive tract were measured by ELISA.The results showed that,Serum sTN- FR-Ⅰ levels were significantly higher in patients with cancer than those in healthy controls (P <0.01);the levels correlated well with clinical staging sTNFR-Ⅰ levels declined 21 days after opera- tion;48 patiens were testsd during 2 to 8 months after surgery;sTNFR-Ⅰ levels decreased further in 16 with tumor removal but elecated in another 32 with disease uncontrolled or with local recurrence or metastasis.This study suggests that measurement of serum sTNFR-Ⅰ in patients with cancer of di- gestive tract is useful for the diagnosis and evaluation of the efficacy of treatment and prognosis.

关 键 词：消化道肿瘤 sTNFR-Ⅰ 治疗 预后 

分 类 号：R735[医药卫生—肿瘤]