CHOP和CHOEP方案治疗非霍奇金淋巴瘤的临床观察  

Clinical observation of CHOP regimen and CHOEP regimen in the treatment of Non-Hodgkin’s lymphoma

作　　者：李涛[1] 苏炳光[2] 凌华晃[2] 蔡茂德[2] 吴祥成[2] 

机构地区：[1]广东医学院2004级硕士研究生2班,广东湛江524023 [2]高州市人民医院肿瘤化疗科,广东高州525200

出　　处：《中华肿瘤防治杂志》2007年第13期1019-1020,共2页Chinese Journal of Cancer Prevention and Treatment

摘　　要：观察2周CHOP(环磷酰胺+阿霉素+长春新碱+强的松)方案和CHOEP方案治疗非霍奇金淋巴瘤(Non-Hodgkin’slymphoma,NHL)的有效性和毒副反应。将51例NHL患者随机分3组,分别采用标准CHOP、CHOEP和CHOP-14方案治疗并观察疗效和毒副反应。51例中CR29例,PR16例,总有效率(OR)88.2%(CR+PR),各组的CR和OR分别为50.0%和85.0%(CHOP),56.0%和87.5%(CHOEP),66.7%和93.3%(CHOP-14)。CHOEP和CHOP-14对NHL的疗效比标准CHOP有提高的趋势,但各组之间CR和OR差异无统计学意义,各组之间毒副反应相似。CHOEP和CHOP-14均可作为NHL安全有效的化疗方案。To observe the effect and toxicity of biweekly CHOP regimen and CHOEP regimen in the treatment of Non-Hodgkin＇s lymphoma. Fifty-one case of NHL were randomly allocated into three groups： Patients respectively received standard CHOP, CHOEP and CHOP-14 regimen, we observe the effect and toxicity. Of 50 cases,29 received CR, 16 received PR, Overall response （OR） rates were 88.2% （CR＋PR） ,CR and OR were 50.0% and 85.0% ,respectively, for CHOP, 56.0% and 87.5%, respectively, for CHOEP and 66.7% and 93.3%, respectively, for CHOP-14,there were a good tendency for patients treated with CHOEP and CHOP-14 regimen, while there were no significantly difference for CR ,OR and toxicity among three groups. CHOEP and CHOP-14 should be considered safe and effective chemotherapy regimens for patients with Non-Hodgkin＇s lymphoma.

关 键 词：非霍奇金淋巴瘤 联合化疗 CHOP 

分 类 号：R733.1[医药卫生—肿瘤]