食管鳞状细胞癌中Survivin和COX-2的表达与临床病理因素的关系  

Correlation of Survivin and COX-2 expression and clinicopathologic factors in esophageal squamous cell carcinoma

作　　者：邹磊[1] 李道堂[1] 穆殿斌[2] 李辉[1] 罗景玉[1] 刘曙光[1] 

机构地区：[1]山东省肿瘤医院胸外科,济南市250117 [2]山东省肿瘤防治研究院病理科

出　　处：《中国肿瘤临床》2007年第12期670-673,共4页Chinese Journal of Clinical Oncology

基　　金：山东省卫生厅科研基金资助(编号:2005HW137)

摘　　要：目的:探讨凋亡抑制蛋白Survivin和COX-2在食管鳞状细胞癌中的表达及相关性。方法:应用免疫组织化学SP法检测Survivin和COX-2蛋白在51例食管鳞状细胞癌和30例切缘正常食管粘膜中的表达,分析Survivin和COX-2表达与食管鳞状细胞癌临床病理因素的关系及两者的相关性。结果:食管鳞状细胞癌组织和切缘正常食管粘膜中,Survivin蛋白阳性率分别为74.51%和6.67%;COX-2蛋白阳性率分别为56.86%和16.67%。统计学分析结果表明,Survivin和COX-2在食管鳞状细胞癌的表达均高于切缘正常食管粘膜(Р<0.01)。Survivin蛋白在食管鳞状细胞癌中的表达阳性率与性别、年龄、肿瘤大小、TNM分期、淋巴结转移等因素无关(Р>0.05),但与肿瘤分化程度相关(Р<0.05)。COX-2蛋白在食管鳞状细胞癌的表达阳性率性别、年龄、肿瘤大小、肿瘤分化程度、TNM分期、淋巴结转移等因素均无关(Р>0.05)。51例食管鳞状细胞癌组织中Survivin与COX-2之间具有显著正相关性(Р<0.01)。结论:Survivin与COX-2蛋白在食管鳞状细胞癌中均过表达,可能是食管鳞状细胞癌发生的早期事件。并且两者表达具有相关性,提示Survivin与COX-2可能存在一个共同的分子通路,并在食管鳞状细胞癌发生、发展中增强各自的作用。在食管鳞状细胞癌中两者关系的分子基础值得进一步研究。Objective： To investigate the expression of Survivin and COX-2 in esophageal squamous cell carcinoma （ESCC） and to determine if there is a correlation between these expression levels and clinicopathologic factors. Methods： The presence and the level of expression of Survivin and COX-2 were detected by S-P immunohistochemistry in 51 ESCC specimens and 30 specimens from the incision margin （TIM）. The expression levels of Survivin and COX-2 were analyzed in relation to the clinicopathologic factors. Results： The positive staining rates of Survivin and COX-2 in ESCC and TIM were 74.51% and 6.67%, 56.86% and 16.67%, respectively. Survivin and COX-2 were expressed at significantly different levels in ESCC and TIM （P〈0.01）. The positive rates of Survivin expression were associated with the differentiation grade of ESCC（P〈0.05）, but were not associated with gender, age, tumor size, depth of invasion, TNM stage or lymph node metastasis（P〉0.05）. The positive rates of COX-2 expression were not associated with gender, age, tumor size, differentiation, depth of invasion, TNM stage or lymph node metastasis （P〉0.05）. The expression of Survivin in ESCC was positively correlated with that of COX-2 in the 51 ESCC samples（P〈0.01）. Conclusion： Both Survivin and COX-2 are overexpressed in ESCC and this overexpression seems to be an earlv event in the development of ESCC.Moreover. expression of these two gene products is positively correlated. Survivin and COX-2 might share a common molecular pathway or enhance each other＇s actions in the development of ESCC. The molecular basis of such a relationship should be investigated further.

关 键 词：食管肿瘤 SURVIVIN COX-2 免疫组织化学 

分 类 号：R735.1[医药卫生—肿瘤]