结直肠癌中c-erbB-2和E-cadherin蛋白表达与临床病理关系  

Relationship Between Expression c-erbB-2 and E-cadherin Protein in Colorectal Cancer and Clinical Pathological Features

作　　者：谷化平[1,2] 周翠玲[3] 

机构地区：[1]解放军第251医院病理科 [2]河北北方学院第一附属医院普外科,中国河北张家口075000 [3]河北北方学院第一附属医院普外科

出　　处：《生命科学研究》2007年第2期158-160,共3页Life Science Research

摘　　要：为了探讨c-erbB-2和E-cadherin(E-cad)蛋白表达与结直肠癌浸润转移的关系及相关性.应用免疫组织化学技术,检测90例结直肠癌中c-erbB-2和E-cad蛋白表达.结果表明:90例结直肠癌中c-erbB-2和E-cad蛋白阳性表达率分别为52.2%(47/90)和46.7%(42/90).c-erbB-2高表达及E-cad低表达与结直肠癌Dukes分期、浆膜浸润和淋巴结转移均呈正相关(P<0.05).结直肠癌中c-erbB-2表达与E-cad表达呈负相关(P<0.05).c-erbB-2和E-cad表达与结直肠癌浸润转移密切相关.联合检测其蛋白表达可作为判断结直肠癌预后的客观指标.To study the relationship between expression of c-erbB-2,E-cadherin （E-cad） and invasion and metastasis in colorectal cancer （CRC）,and the correlation between expression of c-erbB-2 and E-cad. Immunohistochemical staining has used to detect the expression of c-erbB-2 and E-cad in 90 cases of CRC. Our results showed that the expression of c-erbB-2 and E-cad were 52.2% （47 / 90）and 46.7% （42 / 90）, respectively. The high level expression of c-erbB-2 and the low level expression of E-cad were positively correlated with the Dukes staging,serosa infiltration and lymph node metastasis of CRC （P 〈 0.05）. Positively associated with the expression of c-erbB-2 and negatively with that of E-cad（P 〈 0.05）. These data showed a correlation between the c-erbB-2 and E-cad expression and the potential of invasion and metas-tasis in CRC. c-erbB-2 and E-cad which can be used as prognostic indicators in CRC.

关 键 词：结直肠癌 C-ERBB-2基因 E-CADHERIN蛋白 免疫组织化学 

分 类 号：R735.3[医药卫生—肿瘤]