N,N'-双(4-羰甲氧苯基)脲的新合成法  

A Novel Catalytic Synthesis of N N Bis (4 Carbomethoxy Pheayl) Urea

作　　者：王颖[1,2] 张善言[1,2] 

机构地区：[1]贵阳医学院药学系有机教研室 [2]四川大学化学系

出　　处：《贵阳医学院学报》1997年第1期10-13,共4页Journal of Guiyang Medical College

摘　　要：以对－硝基苯甲酸甲酯为底物，三乙胺为助催化剂，少量水为引发剂，经硒催化还原羰基化合成Ｎ，Ｎ－双（４－羰甲氧苯基）脲，并对反应物配比、反应温度、反应时间及一氧化碳压力作了详细研究。所得Ｎ，Ｎ－双（４－羰甲氧苯基）脲的产率达７１．１％。In this paper, a novel catalytic synthesis of N N Bis(4 carbomethoxy phenyl) urea is reported We synthesis the urea by reductive cobonylation Selenium was used as a catalyst and triethylamine as a promoter As a initiator, water was adopted The reaction of P Nitro benzoic acid methyl ester with carbon monoxide was studied cerefully The optimum reaction temperature, reaction time, pressure of carbon monoxide and ratio of reactants were selected Under optimum conditions, the urea was obtained in 71 1% yield

关 键 词：硝基苯甲酸甲酯 合成 脲 

分 类 号：R914.4[医药卫生—药物化学]