聚山梨酯80改进布洛芬片溶出度的工艺探讨  

Ibuprofen tablet dissolution improved by polysorbate 80

作　　者：王立余[1] 黄敬芝 王茹 

机构地区：[1]淮南市抗生素药厂

出　　处：《中国药学杂志》1997年第3期165-166,共2页Chinese Pharmaceutical Journal

摘　　要：目的：探讨制备布洛芬片新的工艺条件，以达到中国药典１９９５年版新标准。方法：用适宜浓度的聚山梨酯８０制粒。结果：颗粒完好，片面光洁，溶出度由原来５２．８６％提高到９４．２６％。结论：为片剂溶出度的改进提供了一种新的方法。OBJECTIVE:To study the preparation techniques of ibuprofen tablet to meet the standard of Chinese pharmacopoeia 1995.METHODS:A proportion of polysorbate 80 was added into atom.RESULTS:Particle size was perfect and the apperance of tablet was smooth.The dissolution was improved from 52.86% to 94.26%.CONCLUSION:A new way was developed to improve the tablet dissolution.

关 键 词：布洛芬片 聚山梨酯80 溶出度 片剂 

分 类 号：R971.1[医药卫生—药品] R944.4[医药卫生—药学]