SDF-1/CXCR4生物学轴与肿瘤关系的研究进展  

Research progress on SDF-1/CXCR4 axis in tumor

作　　者：陈琼[1] 武明花[1] 李桂源[1] 

机构地区：[1]中南大学肿瘤研究所,长沙410078

出　　处：《国际病理科学与临床杂志》2007年第3期227-230,共4页Journal of International Pathology and Clinical Medicine

基　　金：国家重大科学研究计划(2006CB910500);中国博士后科学基金(20060400265);湖南省自然科学基金(06JJ20080)~~

摘　　要：趋化因子SDF-1,又称CXCL12,PBSF,与其特异性受体CXCR4广泛表达在多种组织和器官上,它们所构成的SDF-1/CXCR4生物学轴在多种肿瘤的发生,发展以及转移中都发挥重要作用,其可能是通过MAPK,AKT通路发挥作用。对这一特殊生物学轴的研究可能为肿瘤防治找到新的突破口。SDF-1 （stromal cell- derived factor-1 ） , also known as CXCL12, PBSF,is a member of CXC sub-family chemokines. Various tumor cells express chemokine SDF-1 and it＇s receptor CXCR4, and they constitute a special biological axis of SDF-1/CXCR4 ,which is closely related to development and metastasis of tumor cells through MAPK or Akt signaling wide clinical application in the prevention and treatment pathway. Research on this axis may provide a of tumor.

关 键 词：SDF-1: CXCR4 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]