面颈部皮肤钙化上皮瘤临床及病理研究  

Clinicopathologic Study of Pilomatricoma (Calcifying Epithelioma of Malherbe) in Head and Neck

作　　者：陆东辉[1] 陈菲[2] 王铁梅[3] 

机构地区：[1]南京大学医学院附属口腔医院颌面外科,江苏南京210008 [2]南京大学医学院附属口腔医院病理科 [3]南京大学医学院附属口腔医院放射科

出　　处：《口腔医学研究》2007年第3期297-299,共3页Journal of Oral Science Research

摘　　要：目的:面颈部皮肤钙化上皮瘤为一类较少见的真性肿瘤,本文总结并讨论其临床及病理特点。方法:收集南京口腔医院颌面外科及病理科1991～2005年已经确诊并经手术治疗的钙化上皮瘤共9例临床病案进行回顾性分析。结果:本病患者以青少年俱多,其中～19岁组占42%,P<0.05,性别趋向女性,男女之比为1:2。本病临床上极易误诊,本文资料中9例其误诊率达66%。组织病理观察,表现为影细胞及嗜硷性细胞片状排列为特征。本病经外科手术切除后未见复发。结论:皮肤钙化上皮瘤好发于青少年,且女性占多数。钙化上皮瘤临床易发生误诊,利用影像学手段可提高诊断率。手术切除彻底可以预防复发。Objective： To present a clinicopathologic characteristic of pilomatricoma （calcifying epithelioma of malherbe） which is a rare neoplasm in head and neck. Methods： A retrospective study was carried out in 9 patients with pilomatricoma during the past 15 years （1991 -2005 ） at the department of oral -maxillofacial surgery and pathology, Nanjing Stomatologic Hospital. Results： The age ranged from 12 to 52 years. Fourty - two percent of the cases were observed before the age of 20 years. There was a preponderance in females and female - to - male ratio was 2 ： 1. About 66% of the patients with pilomatricoma appeared a false diagnosis. Piomatricoma was described as a skin tumour histologically composed of ＂ shadow＂ cells, basophillic cells, foreign body cells and intracellular and stromal calcification. The treatment was excision and no recurrences were found by follow - up. Conclusion： Most patients with pilomatricoma were under 20 years or younger and females were affected more often than males. Imaging studies including Ultrasonography, MRI and CT scanning would help to establish the diagnosis. Surgical excision with clear margins and its overlying skin was recommended.

关 键 词：毛母质瘤 皮肤钙化上皮瘤 

分 类 号：R739.8[医药卫生—肿瘤] R739.91[医药卫生—临床医学]