磷脂与非酒精性脂肪性肝病关系的研究  

Study on the Relationship between Phospholipids and Nonalcoholic Fatty Liver Disease

作　　者：蔡红慧[1] 杨丽萍[1] 徐根云[1] 韩阳[1] 厉有名[1] 

机构地区：[1]浙江大学医学院附属第一医院,浙江杭州310003

出　　处：《浙江预防医学》2007年第7期5-6,共2页Zhejiang Journal of Preventive Medicine

摘　　要：目的研究磷脂与非酒精性脂肪性肝病(NAFLD)的关系,了解NAFLD患者脂质代谢紊乱的特点。方法采用酶法测定血清磷脂(PL),并以甘油三酯(TG)、胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、极低密度脂蛋白胆固醇(VLDL-C)、空腹血糖(FPG)及肝酶等作为其他观察指标。结果NAFLD组血清磷脂值为(250.23±55.24)mg/dl,对照组为(229.23±39.03)mg/dl,相比较有显著性差异(t=3.12,P<0.01)。NAFLD组TC、TG、VLDL-C、FBS、ALT、AST、GCT明显高于对照组,两组间差异有统计学意义(P<0.01)。NAFLD组AKP高于对照组(P<0.05)。而NAFLD组HDL-C低于对照组,两组间差异有统计学意义(P<0.01)。结论NAFLD患者存在明显的脂质代谢紊乱,磷脂的代谢障碍造成血清磷脂升高。Objective To investigate the relationship between phospholipids and nonalcoholic fatty liver disease （NAFLD） and to learn the characters of lipid metabolic disorder in NAFLD patients, Methods Serum phospholipase was measured by enzyme couple assays, and other observational indexes included serum total triglycofide （TG）, total cholesterol （TC）, high- density lipoprotein cholesterol （HDL-C）, low-density ]ipoprotein （LDL-C）, very low-density ]ipoprotein cholesterol （VLDL- C）, fasting plasma glucose （FPG） and hepatitis enzyme, Results the serum phospholipase of NAFLD patients （250.23 ：t： 55,24mg/dL） was significantly higher than the controls （229.23 ：t： 39.03mg/dL）, t = 3.12, P 〈 0,01, TC, TG, VLDL-C, FPG, ALT, AST, and GGT in NAFLD group were higher compared with those in control group （P 〈 0.01）, AKP in NAFLD group was also higher than that in control group （P 〈 0.05） while HDL-C was lower in NAFLD patients rather than in controls （P〈0.01）. Conclusions There exists obviously lipid metabolic disorder in NAFLD patients, which causes metabolism disturbances of phospholipids and may lead to increase of serum phospholipids,

关 键 词：非酒精性脂肪性肝病 磷脂 脂质代谢紊乱 

分 类 号：R575.5[医药卫生—消化系统]