营养性肥胖大鼠模型的建立与血糖、血脂变化  

Establishment of adult alimentary obese rats models and obsevation of the changes of glucose and lipid

作　　者：杜文华[1] 石建华[1] 项平[2] 陈凤玲[1] 

机构地区：[1]蚌埠医学院第一附属医院内分泌科,安徽蚌埠233004 [2]蚌埠医学院第一附属医院中心实验室,安徽蚌埠233004

出　　处：《蚌埠医学院学报》2007年第4期379-381,共3页Journal of Bengbu Medical College

基　　金：国家自然科学基金资助项目(No.30440026)

摘　　要：目的:建立贴近临床的营养性肥胖大鼠模型,观察肥胖大鼠模型的形态与血糖、血脂变化情况。方法:用高脂饲料喂养成年大鼠80天,观测大鼠体重、体长、Lee’s指数及血糖、血脂水平。结果:应用高脂饲料喂养后,大鼠体重、体长、Lee’s指数与对照组差异均有统计学意义(P<0.001),大鼠的血糖、甘油三酯、总胆固醇和低密度脂蛋白均明显高于对照组(P<0.01～P<0.001),而高密度脂蛋白明显低于对照组(P<0.001)。结论:高脂饲料可以使成年大鼠发生营养性肥胖,肥胖大鼠的血糖、血脂水平与对照组相比差异有统计学意义。Objective： To establish adult alimentary obese rats models and observe their changes in appearance, serum levels of glucose and lipid. Methods：The rats were fed with high fat food for 80 days and their weight ,length and Lee＇s index were observed. Results ：The weight ,length and Lee＇s index had significant difference between the control group and the models（ P 〈 0. 001 ）. Fat rats had higher serum levels of glucose, triglyceride, total cholesterol and low-density lipoprotein, but lower high-density lipoprotein than normal rats（P 〈 0, 01 -P 〈 0. 001 ）. Concluslons：High fat food may cause alimentary obesity in aduh rats, and there＇s significant difference in serum levels of glucose and lipid between the normal and obese rats.

关 键 词：肥胖 模型 动物 大鼠 高脂饲料 Lee's指数 血糖 血脂 

分 类 号：R151.1[医药卫生—营养与食品卫生学]