HLA基因多态性与溃疡性结肠炎遗传易感关系的研究  

Study on the association between DRB1 allele polymorphism and the genetic susceptibility in patients with ulcerative colitis

作　　者：王丽英[1] 王江滨[2] 杨俊玲[3] 

机构地区：[1]吉林大学第二医院消化内科,长春130041 [2]吉林大学中日联谊医院消化内科,长春130031 [3]吉林大学第二医院呼吸科,长春130041

出　　处：《中国免疫学杂志》2007年第2期131-133,共3页Chinese Journal of Immunology

基　　金：国家自然科学基金资助(No.30070339)

摘　　要：目的:研究HLA-DRB1等位基因多态性与我国汉族溃疡性结肠炎遗传易感的相关性,并分析其与疾病临床分型的相关性。方法:应用基因芯片技术分析了本地区汉族溃疡性结肠炎60例患者和健康对照者DRB1的基因分型,采用Fisher’s精确概率法比较了两组各位点等位基因频率分布的差异。结果:溃疡性结肠炎患者DR2和DRB1*15基因表达频率分别为45%和41.7%,较对照组(23.3%和21.7%)明显升高,OR分别为2.688和2.582(均P<0.05)。慢性持续型UC的DRB1*15等位基因频率较相应其他型升高更为显著(P<0.05)。结论:DR2或DRB1*15等位基因可能是我国汉族人群UC的易感基因。HLA-DR基因多态性与UC的临床分型密切相关。Objective：To assess human leucocyte antigen（HLA）-DRB1 allele polymorphism and analyze the association between DRB1 allele polymorphism and clinical classification of ulcerative colitis. Methods：60 patients were investigated for DRB1 gene by DNA microarray. The results were compared with those from healthy subjects. Results：The frequency of DR2 and DRB1 ＊ 15 in UC patients were 45% and 41.7% respectively,which were significantly higher than those（23.3% and 21.7% ） in controls,the odds ratio being 2. 688 and 2. 582 respeetively（P 〈0. 05）, the frequency of DRB1 ＊ 15 allele in chronic persistant UC patients was significantly higher than that in other types of UC （P 〈 0.05 ）. Conclusion： DR2 or DRB1 ＊ 15 may be the susceptibility genes in patients with UC in Chinese Han nationality. HLA-DR allele polymorphism is associated with clinical classification of UC.

关 键 词：人类白细胞抗原DRB1基因 溃疡型结肠炎 遗传易感性 

分 类 号：R574.62[医药卫生—消化系统]