碱性成纤维细胞生长因子在胃癌中的表达及意义(附170例分析)  

Expression and significance of bFGF in gastric carcinoma:Analysis of 170 cases

作　　者：谢家泰[1] 陈宏斌[1] 蒋义贵[1] 林敏[1] 卞意萍[1] 

机构地区：[1]福建医科大学附属三明第一医院消化内科,365000

出　　处：《福建医药杂志》2007年第3期14-16,共3页Fujian Medical Journal

摘　　要：目的研究胃癌(gastric carcinoma,GC)组织中碱性成纤维细胞生长因子(bFGF)的表达规律。方法用免疫组织化学染色(SP法)检测慢性浅表性胃炎(chronic superficial gastritis,CSG)、胃黏膜肠上皮化生(intestinal metaplasia,IM)、异型增生(dysplasia,Dys)和胃癌组织标本中bFGF阳性表达情况。结果在CSG→IM→Dys→GC的过程中,bFGF的表达呈逐步递增趋势,bFGF的阳性表达率GC组与Dys、IM组,差异均具有统计学意义(P<0.05),胃癌组bFGF阳性表达率均高于相应癌旁组,差异有统计学意义(P<0.05)。结论胃癌形成过程中,bFGF表达逐渐上调。Objective To study the expression of basic fibroblast growth factor （bFGF）. Method Expression of bFGF were dectected by immunohistochemistry （S-P method）. Result Expression of bFGF showed a gradually increasing tendency from CSG, IM, Dys to GC. There was a significant difference between GC and IM, Dys. Conclusion Expression of bFGF show a gradually increasing tendency in gastric carcinogensis.

关 键 词：胃癌 碱性成纤维细胞生长因子 

分 类 号：R735.2[医药卫生—肿瘤]