家族性胰腺癌  

Familial pancreatic cancer

作　　者：张建伟[1] 王成锋[1] 

机构地区：[1]中国医学科学院中国协和医科大学肿瘤医院腹部外科,北京100021

出　　处：《国际外科学杂志》2007年第7期476-479,共4页International Journal of Surgery

摘　　要：家族性胰腺癌（familial pancreatic cancer，FPC）是已经确定的遗传肿瘤综合征，占全部胰腺癌的3％左右。因此，对FPC的研究将有利于发现胰腺癌的高危人群，包括家族中出现胰腺癌的其他成员和其他遗传肿瘤综合征：如皮肤黏膜黑色素斑一胃肠道多发性息肉综合征（Peutz—Jeghers综合征），家族性非典型恶性黑色素瘤，家族性乳腺卵巢癌综合征，遗传性非腺瘤性结直肠癌等。胰腺癌易患基因和环境因素的确定将能够更加准确预测发病的危险，加强对高危人群的随访和及时的根治性手术是改善预后的重要方法。Familial pancreatic cancer （FPC）, an established hereditary tumor entity is responsible for approximately 3% of pancreatic cancer. Therefore, analysis of the family history nlay help to identify individuals with high risk of developing PC. These include family members with a history of PC as well as those with distinct hereditary cancer syndromes such as Peutz-Jeghers syndrome, hereditary pancreatitis ,familial atypical multiple mole melanoma syndrome, hereditary breast and ovarian cancer syndrome and hereditarynon- polyposis colorectal cancer. In the future, the identification of the murat genes predisposing to PC the analysis of exogenous risk factors could forcast cise risk assessment for the development of PC. Providing surveillance and timely curative pancreatectomy to high-risk individuals is cornerstone to the prognosis.

关 键 词：家族性胰腺癌 遗传 病因 治疗 

分 类 号：R735[医药卫生—肿瘤]