青年抑郁症患者基底节和丘脑3D ~1H-MRS研究  

Three-dimension ~1H MR Spectroscopy of Basal Ganglion and Thalamus in Young Patients with Major Depression

作　　者：李建军[1,2] 林明方[3] 孔祥泉[1] 王桂华[4] 蒋湘玲[3] 郭敏[3] 

机构地区：[1]华中科技大学同济医学院附属协和医院放射科 [2]海南省人民医院放射科,海口570311 [3]海南省人民医院心理咨询与治疗中心 [4]海南省人民医院放射科

出　　处：《放射学实践》2007年第7期679-682,共4页Radiologic Practice

基　　金：海南省卫生厅科研资助项目(琼卫2005-73号)

摘　　要：目的:探讨青年抑郁症患者基底节和丘脑可能存在的神经生化异常。方法:对44例青年抑郁症患者(抑郁症组)和40例年龄和性别匹配的健康志愿者(对照组)进行常规MRI扫描和三维氢质子MR波谱(3D ~1H-MRS)检查,测量双侧基底节和丘脑的N-乙酰天门冬氨酸(NAA)、胆碱复合物(Cho)、肌醇(mI)和肌酸(Cr)的绝对值,并计算它们与Cr的比值。对两组实验对象各代谢物及其比值进行统计学分析。结果:①抑郁症组双侧豆状核和尾状核头部Cho/Cr、mI/Cr明显高于对照组,差异有显著性意义(P<0.05),而NAA/Cr在两组间差异无统计学意义(P>0.05);②抑郁症组丘脑NAA/Cr、Cho/Cr和mI/Cr与对照组相比,差异无统计学意义(P>0.05)。结论:青年抑郁症患者基底节区豆状核和尾状核头部的Cho/Cr、mI/Cr增高,可能构成该病的神经生物学基础。Objective：To study the possibly neurochemical abnormalities in the basal ganglia and thalamus of young patients with major depression （MD）. Methods.. Routine MRI and 3-dimension ： H MR spectroscopy were performed in 44 patients with major depression （MD） and 40 gender and age-matched healthy controls. The neurochemical abnormalities included the levels of N-acetylaspartate （NAA） choline （Cho）, myo-inositol （mI） and creatine （Cr） of basal ganglion and thalamus were measured with three-dimension ^1H MR spectroscopy （3D-1 H MRS）, the ratio of the values of above-mentioned items with CR were calculated. Results：The Cho/Cr and mI/Cr ratios in bilateral lentiform nucleus and the head of caudate nucleus were significantly higher in MD group patients than that in control group （P〈0.05）, but there were no statistical significant difference in the NAA/Cr ratio between the two groups （P^0.05）. There were no significant difference statistically in the NAA/Cr,Cho/Cr,and mI/Cr ratios in thalamus between the two groups as well （P〉0.05）. Conclusion： In young MD patients, the values of Cho/Cr and mI/Cr ratios in both bilateral lentiform nucleus and the head of caudate nucleus increased,it might possibly be the neurobiological basis of MD.

关 键 词：磁共振成像 磁共振波谱学 抑郁症 基底节 丘脑 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]