门冬氨酸鸟氨酸对肿瘤化疗药物性肝损害的保护作用  

Protetive Effect of Orinithine Aspartrate on the Liver Function Damaged by Chemotherapy of Malignant Tumor

作　　者：李丹[1] 曾波航[1] 

机构地区：[1]广州医学院第二附属医院肿瘤科,广东广州510260

出　　处：《国际医药卫生导报》2007年第14期27-29,共3页International Medicine and Health Guidance News

摘　　要：目的：探讨门冬氨酸鸟氨酸在恶性肿瘤化疗药物性肝损害的保护作用。方法：102例患者分为化疗加门冬氨酸鸟氨酸护肝组与单纯化疗组，护肝组在化疗前1天及化疗中每日静滴7．5g门冬氨酸鸟氨酸，治疗期间每2周复查肝功能。结果：护肝化疗组与单纯化疗组比较，肝功能损害发生率低，分别为10．8％和29．4％（x^2=6．22，P〈0.05），护肝化疗组无Ⅲ／Ⅳ度肝功能损害，经秩和检验证明两组肝功能损害程度分布上差异有统计学意义（P〈0．01）。结论：化疗联合用门冬氨酸鸟氧酸可预防并减少化疗对肝脏的损害，提高病人对治疗的耐受性。Objective To explore the protective effect of Ornithine Aspartate （OA） assisted with chemotherapy in patient of malignant tumor. Methods 102 cases of the patient were divide into the group of chemotherapy alone and the group of chemotherapy combined with OA, the combined group were treated with OA （7. 5g perday venous instillation） during the chemotherapy and before 1 day, liver function were detected to evaluate the effect every 2 week. Results Comparing the results of the group of chemotherapy combined with that of the group of chemotherapy alone, the occurrence of liver function damage was lower, these tow groups were 10.8% and 29.4% respectively（x ^2=6.22, P〈0.05）,the combined group without degree Ⅲ/Ⅳ liver function damage. A rank sum test to analyze the distribution of impairment degree showed that there was a significant difference between these two groups（P〈0.01）. Conclusion Ornithie Aspartate was effective in the prevention and treatment of the liver function damage caused by chemotherapy in patients of malignamt tumor, it may improve liver function and ensure the continuity of the treatment.

关 键 词：门冬氨酸鸟氨酸 肿瘤 化疗 肝功能损害 

分 类 号：R575[医药卫生—消化系统] R730[医药卫生—内科学]