自体外周血造血干细胞移植治疗小儿白血病、恶性肿瘤的临床研究  

Analysis of the therapeutic effects of autologous peripheral blood stem cell transplantation on malignant tumors in children

作　　者：吕善根[1] 唐锁勤[1] 冉崇蓉[1] 魏晓军[1] 黄东生[1] 马立群[1] 王建文[1] 张建忠[1] 

机构地区：[1]解放军总医院儿科

出　　处：《中华儿科杂志》1997年第5期233-235,共3页Chinese Journal of Pediatrics

摘　　要：为探讨预处理方案对小儿自体外周血造血干细胞移植（Ａｕｔｏ－ＰＢＳＣＴ）疗效的影响，对１４例恶性肿瘤患儿（急性淋巴细胞白血病７例、急性髓系白血病４例、恶性淋巴瘤２例、神经母细胞瘤１例），在其完全缓解６个月后进行了Ａｕｔｏ－ＰＢＳＣＴ治疗。中位随访时间４．８年（３～７年）。结果无病生存率为５７％（８／１４），死亡率为４３％（６／１４）。初步资料结果表明，预处理方案采用全身照射（７．０±０．５Ｇｙ）联合３或４种化疗药物要比联合１～２或５种化疗药物为好，但在为每个患儿进行移植前制订预处理方案时，应注意个体化。To investigate the preparative regimen of autologous peripheral blood stem cell transplantation (Auto PBSCT) for Chinese children, 14 patients with malignant tumors including acute lymphoblastic leukemia (ALL) in 7 cases, acute myeloid leukemia in 4 cases, malignant lymphoma in 2 cases and neuroblastoma in 1 case were treated with Auto PBSCT 6 months after complete remission (CR). A median of 4.8 years (range, 3～7 years) follow up showed that the disease free survival (DFS) and death rates were 57% (8/14) and 43% (6/14), respectively. The preliminary results suggested that total body irradiation (7.0±0.5 Gy) combined with 3 or 4 chemotherapeutic drugs produced better therapeutic effects than that combined with 1～2 or 5 chemotherapeutic drugs. However, individuation must be put into the preparative regimen for patients.

关 键 词：白血病 外周血 自体移植 造血干细胞移植 儿童 

分 类 号：R733.705[医药卫生—肿瘤]