近视性光学离焦对幼恒河猴正视化的影响  

Influence of Myopic Optical Defocus on Emmetropization of Infant Rhesus Monkeys

作　　者：吴君舒[1] 葛坚[1] 钟兴武[1] 高前应[1] 黄娟[1] 

机构地区：[1]中山大学中山眼科中心//眼科学国家重点实验室,广东广州510060

出　　处：《中山大学学报（医学科学版）》2007年第4期473-475,共3页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：国家自然科学基金(30100205);教育部新世纪优秀人才支持计划(NCET-04-0812);霍英东青年教师基金(91043)

摘　　要：【目的】研究近视性光学离焦对幼恒河猴正视化过程的影响。【方法】将14只20～40天龄的健康幼恒河猴随机分为A(n=6)、B(n=8)两组,A组猴双眼均配戴+3.00D镜片,造成近视性光学离焦;B组猴双眼均配戴0.00D镜片,作为对照。戴镜前及戴镜后2、4、6、8和12周给所有动物进行屈光度测量、角膜地形图检查、A超测量玻璃体腔长度,以动态观察在两种不同干预条件下,幼猴眼球生长和屈光状态的变化情况。【结果】戴镜前后A、B两组猴右左眼玻璃体腔长度相比较无统计学差异。在观察期内,所有猴眼玻璃体腔长度均逐渐增加。戴镜12周后,近视性离焦猴双眼玻璃体腔长度的增加比对照组猴双眼玻璃体腔长度的增加要少(近视性离焦组0.41mm(S=0.17);对照组0.70mm(S=0.18),P=0.01。戴镜前后所有猴右左眼屈光度相比较均无统计学差异。在观察期内,所有猴双眼均朝向远视度数减少的方向发展,戴镜12周后,近视性离焦猴双眼屈光度减少1.3D(S=1.5),与对照组的2.3D(S=1.3)似较慢,但P=0.205。【结论】近视性离焦可干预幼恒河猴的正视化过程,表现为玻璃体腔生长延缓,形成相对的远视状态,提示临床上婴幼儿屈光不正的矫治要慎重。[Objective] To investigate the influence of myopic optical defocus on the emmetropization of infant rhesus monkeys. [Methods] Fourteen healthy infant rhesus monkeys, between 20 and 40 days of age, were divided into two groups of A （n=6） and B （n=8） by random. The monkeys from group A wore ＋3.00 D spectacle lenses over both of their eyes and relative myopic defocus was produced. The monkeys from group B wore 0.00 D lenses over both of their eyes as control. The monkeys refractive error, corneal topography, vitreous chamber depth were measured at the start of lens wear and at 2, 4, 6, 8, and 12 weeks post-treatment. By these means, we observed the changes of eye growth and refractive status dynamically. [Results] In group A and B, no statistically significant difference was observed between the right and left eyes in vitreous chamber depth pre- and post-treatment. During the course of study, the vitreous chamber depth of all the animals elongated gradually. After lens wear of 12 weeks, the axial eyeball elongation amplitude of myopic defocused monkey eyes was less obvious than that of control group [myopic defocus group 0.41 mm （S=0.17）; control group 0.70 mm （S=0.18）, P=0.01]. There was no statistically significant difference between the right and left eyes in refractive error pre- and post-treatment in all the animals. During the course of observation, both eyes of all the animals became less and less hyperopic. After lens wear of 12 weeks, the reduction of hyperopic diopters seemed slower in myopic defocus group, nevertheless there was no apparently statistically significant difference [myopic defocus group 1.3 D （S=1.5）; control group 2.3 D （S=1.3）, P=0.205]. [Conclusion] Myopic defocus may intervene the process of emmetropization of infant rhesus monkeys, which was characteristic of slower vitreous chamber elongation and hyperopic regression. It offers a new insight that correction of refractive error on children should be careful in our clinical practice.

关 键 词：近视性光学离焦 恒河猴 正视化 屈光不正 

分 类 号：R78[医药卫生—口腔医学]